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Acta Pharmaceutica, Vol. 57 No. 2, 2007.

Izvorni znanstveni članak

Mucuna gum microspheres for oral delivery of glibenclamide: In vitro evaluation

ANTHONY AMAECHI ATTAMA
OBICHUKWU J. NWABUNZE

Puni tekst: engleski, pdf (92 KB) str. 161-171 preuzimanja: 789* citiraj
APA 6th Edition
AMAECHI ATTAMA, A. i NWABUNZE, O.J. (2007). Mucuna gum microspheres for oral delivery of glibenclamide: In vitro evaluation. Acta Pharmaceutica, 57 (2), 161-171. Preuzeto s https://hrcak.srce.hr/9831
MLA 8th Edition
AMAECHI ATTAMA, ANTHONY i OBICHUKWU J. NWABUNZE. "Mucuna gum microspheres for oral delivery of glibenclamide: In vitro evaluation." Acta Pharmaceutica, vol. 57, br. 2, 2007, str. 161-171. https://hrcak.srce.hr/9831. Citirano 24.05.2019.
Chicago 17th Edition
AMAECHI ATTAMA, ANTHONY i OBICHUKWU J. NWABUNZE. "Mucuna gum microspheres for oral delivery of glibenclamide: In vitro evaluation." Acta Pharmaceutica 57, br. 2 (2007): 161-171. https://hrcak.srce.hr/9831
Harvard
AMAECHI ATTAMA, A., i NWABUNZE, O.J. (2007). 'Mucuna gum microspheres for oral delivery of glibenclamide: In vitro evaluation', Acta Pharmaceutica, 57(2), str. 161-171. Preuzeto s: https://hrcak.srce.hr/9831 (Datum pristupa: 24.05.2019.)
Vancouver
AMAECHI ATTAMA A, NWABUNZE OJ. Mucuna gum microspheres for oral delivery of glibenclamide: In vitro evaluation. Acta Pharm. [Internet]. 2007 [pristupljeno 24.05.2019.];57(2):161-171. Dostupno na: https://hrcak.srce.hr/9831
IEEE
A. AMAECHI ATTAMA i O.J. NWABUNZE, "Mucuna gum microspheres for oral delivery of glibenclamide: In vitro evaluation", Acta Pharmaceutica, vol.57, br. 2, str. 161-171, 2007. [Online]. Dostupno na: https://hrcak.srce.hr/9831. [Citirano: 24.05.2019.]

Sažetak
An investigation into the suitability of mucuna gum microspheres for oral delivery of glibenclamide is presented. Mucuna gum microspheres were formulated under different conditions of polymer concentration and crosslinking time at constant speed. The formulated microspheres were thereafter loaded with glibenclamide by the remote loading process. The microspheres were evaluated according to particle size, yield, loading efficiency and swelling. In vitro release of glibenclamide from the microspheres was studied in simulated intestinal fluid (SIF, pH 7.4). The release data was fitted into two release models to investigate the mechanism of glibenclamide release from the microspheres. All the microspheres showed good swelling characteristics in distilled water. The investigation revealed that the microspheres produced with 5% (m/V) mucuna gum with a crosslinking time of 5 h had the optimum prolonged release pattern. The microspheres produced using 10% (m/V) mucuna gum with a crosslinking time of 1 h had the highest delayed release of the incorporated drug whereas those without crosslinking had the fastest release of the incorporated active ingredient. Ritger-Peppas case I transport model appeared to have adequately described the release process as about 54% of the batches of microspheres conformed to this model. This implies that a formulation of glibenclamide-loaded mucuna gum microspheres is likely to offer a reliable means of delivering glibenclamide by the oral route.

Ključne riječi
mucuna gum; microspheres; glibenclamide; in vitro release; oral delivery

Hrčak ID: 9831

URI
https://hrcak.srce.hr/9831

[hrvatski]

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