APA 6th Edition YAMSANI, V.V., GANNU, R., KOLLI, C., RAO, M.E.B. i YAMSANI, M.R. (2007). Development and in vitro evaluation of buccoadhesive carvedilol tablets. Acta Pharmaceutica, 57 (2), 185-197. Preuzeto s https://hrcak.srce.hr/9832
MLA 8th Edition YAMSANI, VAMSHI VISHNU, et al. "Development and in vitro evaluation of buccoadhesive carvedilol tablets." Acta Pharmaceutica, vol. 57, br. 2, 2007, str. 185-197. https://hrcak.srce.hr/9832. Citirano 19.05.2019.
Chicago 17th Edition YAMSANI, VAMSHI VISHNU, RAMESH GANNU, CHANDRASEKHAR KOLLI, M. E. BHANOJI RAO i MADHUSUDAN RAO YAMSANI. "Development and in vitro evaluation of buccoadhesive carvedilol tablets." Acta Pharmaceutica 57, br. 2 (2007): 185-197. https://hrcak.srce.hr/9832
Harvard YAMSANI, V.V., et al. (2007). 'Development and in vitro evaluation of buccoadhesive carvedilol tablets', Acta Pharmaceutica, 57(2), str. 185-197. Preuzeto s: https://hrcak.srce.hr/9832 (Datum pristupa: 19.05.2019.)
Vancouver YAMSANI VV, GANNU R, KOLLI C, RAO MEB, YAMSANI MR. Development and in vitro evaluation of buccoadhesive carvedilol tablets. Acta Pharm. [Internet]. 2007 [pristupljeno 19.05.2019.];57(2):185-197. Dostupno na: https://hrcak.srce.hr/9832
IEEE V.V. YAMSANI, R. GANNU, C. KOLLI, M.E.B. RAO i M.R. YAMSANI, "Development and in vitro evaluation of buccoadhesive carvedilol tablets", Acta Pharmaceutica, vol.57, br. 2, str. 185-197, 2007. [Online]. Dostupno na: https://hrcak.srce.hr/9832. [Citirano: 19.05.2019.]
Sažetak Buccoadhesive tablets of carvedilol were prepared using HPMC K4M, HPMC K15M and Carbopol 934 as mucoadhesive polymers. Fifteen formulations were developed with varying concentrations of polymers. Formulations of the BC or BD series were composed of HPMC K4M or HPMC K15M in ratios of 1:1 to 1:5 whereas in the BE series Carbopol 934 was used (1:0.25 to 1:1.50). The formulations were tested for in vitro drug release, in vitro bioadhesion, moisture absorption and in vitro drug permeation through porcine buccal mucosa. Formulation BC3 showed maximum release of the drug (88.7 ± 0.4%) with the Higuchi model release profile and permeated 21.5 ± 2.9% of the drug (flux 8.35 ± 0.291 µg h1cm2) permeation coefficient 1.34 ± 0.05 cm h1) through porcine buccal membrane. BC3 formulation showed 1.62 ± 0.15 N of peak detachment force and 0.24 ± 0.11 mJ of work of adhesion. FTIR results showed no evidence of interaction between the drug and polymers. XRD study revealed that the drug is in crystalline form in the polymer matrix. The results indicate that suitable bioadhesive buccal tablets with desired permeability could be prepared.