APA 6th Edition GREDIČAK, M. & JERIĆ, I. (2007). Enediyne compounds - new promises in anticancer therapy. Acta Pharmaceutica, 57 (2), 133-150. Retrieved from https://hrcak.srce.hr/9834
MLA 8th Edition GREDIČAK, MATIJA and IVANKA JERIĆ. "Enediyne compounds - new promises in anticancer therapy." Acta Pharmaceutica, vol. 57, no. 2, 2007, pp. 133-150. https://hrcak.srce.hr/9834. Accessed 18 Jun. 2019.
Chicago 17th Edition GREDIČAK, MATIJA and IVANKA JERIĆ. "Enediyne compounds - new promises in anticancer therapy." Acta Pharmaceutica 57, no. 2 (2007): 133-150. https://hrcak.srce.hr/9834
Harvard GREDIČAK, M., and JERIĆ, I. (2007). 'Enediyne compounds - new promises in anticancer therapy', Acta Pharmaceutica, 57(2), pp. 133-150. Available at: https://hrcak.srce.hr/9834 (Accessed 18 June 2019)
Vancouver GREDIČAK M, JERIĆ I. Enediyne compounds - new promises in anticancer therapy. Acta Pharm. [Internet]. 2007 [cited 2019 June 18];57(2):133-150. Available from: https://hrcak.srce.hr/9834
IEEE M. GREDIČAK and I. JERIĆ, "Enediyne compounds - new promises in anticancer therapy", Acta Pharmaceutica, vol.57, no. 2, pp. 133-150, 2007. [Online]. Available: https://hrcak.srce.hr/9834. [Accessed: 18 June 2019]
Abstracts Scientists of all kinds have long been intrigued by the nature, action and potential of natural toxins that possess exceptional antibacterial and anticancer activities. These compounds, named enediynes, are among the most effective chemotherapeutic agents known. Often compared with intelligent weapons, due to the unique structure and sophisticated mechanism by which they destroy double-helical DNA, enediyne antibiotics are nowadays the most promising leaders in the anticancer therapy. Apart from their diversity, enediyne compounds share some structural and functional similarities. One fragment of a structure is responsible for the recognition and transport, another part acts as molecular trigger while the third, reactive enediyne unit, undergoes Bergman cycloaromatization and causes DNA breakage. Members of the enediyne family are already in clinical use to treat various cancers, but more general use is limited by their complex structure, which makes them formidable targets for synthetic chemists. There are three main approaches in the design of new enediyne-related compounds: improvement of enediyne "warheads", increasing the selectivity and control of chemical or photo-induced activation. This paper gives an overview of naturally occurring enediynes, their mode of action and efforts undertaken to design artificial enediyne-related DNA cleaving agents.