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Review article

Enediyne compounds - new promises in anticancer therapy

MATIJA GREDIČAK
IVANKA JERIĆ

Fulltext: english, pdf (236 KB) pages 133-150 downloads: 1.162* cite
APA 6th Edition
GREDIČAK, M. & JERIĆ, I. (2007). Enediyne compounds - new promises in anticancer therapy. Acta Pharmaceutica, 57 (2), 133-150. Retrieved from https://hrcak.srce.hr/9834
MLA 8th Edition
GREDIČAK, MATIJA and IVANKA JERIĆ. "Enediyne compounds - new promises in anticancer therapy." Acta Pharmaceutica, vol. 57, no. 2, 2007, pp. 133-150. https://hrcak.srce.hr/9834. Accessed 20 Sep. 2019.
Chicago 17th Edition
GREDIČAK, MATIJA and IVANKA JERIĆ. "Enediyne compounds - new promises in anticancer therapy." Acta Pharmaceutica 57, no. 2 (2007): 133-150. https://hrcak.srce.hr/9834
Harvard
GREDIČAK, M., and JERIĆ, I. (2007). 'Enediyne compounds - new promises in anticancer therapy', Acta Pharmaceutica, 57(2), pp. 133-150. Available at: https://hrcak.srce.hr/9834 (Accessed 20 September 2019)
Vancouver
GREDIČAK M, JERIĆ I. Enediyne compounds - new promises in anticancer therapy. Acta Pharm. [Internet]. 2007 [cited 2019 September 20];57(2):133-150. Available from: https://hrcak.srce.hr/9834
IEEE
M. GREDIČAK and I. JERIĆ, "Enediyne compounds - new promises in anticancer therapy", Acta Pharmaceutica, vol.57, no. 2, pp. 133-150, 2007. [Online]. Available: https://hrcak.srce.hr/9834. [Accessed: 20 September 2019]

Abstracts
Scientists of all kinds have long been intrigued by the nature, action and potential of natural toxins that possess exceptional antibacterial and anticancer activities. These compounds, named enediynes, are among the most effective chemotherapeutic agents known. Often compared with intelligent weapons, due to the unique structure and sophisticated mechanism by which they destroy double-helical DNA, enediyne antibiotics are nowadays the most promising leaders in the anticancer therapy. Apart from their diversity, enediyne compounds share some structural and functional similarities. One fragment of a structure is responsible for the recognition and transport, another part acts as molecular trigger while the third, reactive enediyne unit, undergoes Bergman cycloaromatization and causes DNA breakage. Members of the enediyne family are already in clinical use to treat various cancers, but more general use is limited by their complex structure, which makes them formidable targets for synthetic chemists. There are three main approaches in the design of new enediyne-related compounds: improvement of enediyne "warheads", increasing the selectivity and control of chemical or photo-induced activation. This paper gives an overview of naturally occurring enediynes, their mode of action and efforts undertaken to design artificial enediyne-related DNA cleaving agents.

Keywords
enediynes; antitumor agents; Bergman cyclization; DNA-cleaving

Hrčak ID: 9834

URI
https://hrcak.srce.hr/9834

[croatian]

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