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Acta Pharmaceutica, Vol. 57 No. 2, 2007.

Kratko priopćenje

Use of ceric ammonium sulphate and two dyes, methyl orange and indigo carmine, in the determination of lansoprazole in pharmaceuticals

KANAKAPURA BASAVAIAH
VEERAIAH RAMAKRISHNA
URDIGERE RANGACHAR ANIL KUMAR

Puni tekst: engleski, pdf (74 KB) str. 211-220 preuzimanja: 1.577* citiraj
APA 6th Edition
BASAVAIAH, K., RAMAKRISHNA, V. i KUMAR, U.R.A. (2007). Use of ceric ammonium sulphate and two dyes, methyl orange and indigo carmine, in the determination of lansoprazole in pharmaceuticals. Acta Pharmaceutica, 57 (2), 211-220. Preuzeto s https://hrcak.srce.hr/9838
MLA 8th Edition
BASAVAIAH, KANAKAPURA, et al. "Use of ceric ammonium sulphate and two dyes, methyl orange and indigo carmine, in the determination of lansoprazole in pharmaceuticals." Acta Pharmaceutica, vol. 57, br. 2, 2007, str. 211-220. https://hrcak.srce.hr/9838. Citirano 24.05.2019.
Chicago 17th Edition
BASAVAIAH, KANAKAPURA, VEERAIAH RAMAKRISHNA i URDIGERE RANGACHAR ANIL KUMAR. "Use of ceric ammonium sulphate and two dyes, methyl orange and indigo carmine, in the determination of lansoprazole in pharmaceuticals." Acta Pharmaceutica 57, br. 2 (2007): 211-220. https://hrcak.srce.hr/9838
Harvard
BASAVAIAH, K., RAMAKRISHNA, V., i KUMAR, U.R.A. (2007). 'Use of ceric ammonium sulphate and two dyes, methyl orange and indigo carmine, in the determination of lansoprazole in pharmaceuticals', Acta Pharmaceutica, 57(2), str. 211-220. Preuzeto s: https://hrcak.srce.hr/9838 (Datum pristupa: 24.05.2019.)
Vancouver
BASAVAIAH K, RAMAKRISHNA V, KUMAR URA. Use of ceric ammonium sulphate and two dyes, methyl orange and indigo carmine, in the determination of lansoprazole in pharmaceuticals. Acta Pharm. [Internet]. 2007 [pristupljeno 24.05.2019.];57(2):211-220. Dostupno na: https://hrcak.srce.hr/9838
IEEE
K. BASAVAIAH, V. RAMAKRISHNA i U.R.A. KUMAR, "Use of ceric ammonium sulphate and two dyes, methyl orange and indigo carmine, in the determination of lansoprazole in pharmaceuticals", Acta Pharmaceutica, vol.57, br. 2, str. 211-220, 2007. [Online]. Dostupno na: https://hrcak.srce.hr/9838. [Citirano: 24.05.2019.]

Sažetak
Two spectrophotometric methods are proposed for the assay of lansoprazole (LPZ) in bulk drug and in dosage forms using ceric ammonium sulphate (CAS) and two dyes, methyl orange and indigo carmine, as reagents. The methods involve addition of a known excess of CAS to LPZ in acid medium, followed by determination of residual CAS by reacting with a fixed amount of either methyl orange, measuring the absorbance at 520 nm (method A), or indigo carmine, measuring the absorbance at 610 nm (method B). In both methods, the amount of CAS reacted corresponds to the amount of LPZ and the measured absorbance was found to increase linearly with the concentration of LPZ, which is corroborated by the correlation coefficients of 0.9979 and 0.9954 for methods A and B, respectively. The systems obey Beer’s law for 0.5–7.0 g mL-1 and 0.25–3.0 g mL-1 for methods A and B, respectively. The apparent molar absorptivities were calculated to be 3.0  104 and 4.4  104 L mol-1 cm-1 for methods A and B, respectively. The limits of detection (LOD) and quantification (LOQ) are calculated to be 0.08 and 0.25 g mL-1 for method A, and 0.09 and 0.27 g mL-1 for method B, respectively. The intra-day and inter-day precision and accuracy of the methods were evaluated according to the current ICH guidelines. Both methods were of comparable accuracy (er ≤ 2%). Also, both methods are equally precise as shown by the relative standard deviation values < 1.5%. No interference was observed from common pharmaceutical adjuvants. The accuracy of the methods was further ascertained by performing recovery studies using the standard addition method. The methods were successfully applied to the assay of LPZ in capsule preparations and the results were statistically compared with those of the literature UV-spectrophotometric method by applying Student’s t-test and F-test.

Ključne riječi
lansoprazole; determination; spectrophotometry; ceric ammonium sulphate; methyl orange; indigo carmine; pharmaceuticals

Hrčak ID: 9838

URI
https://hrcak.srce.hr/9838

[hrvatski]

Posjeta: 2.096 *