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Izvorni znanstveni članak
https://doi.org/10.2498/cit.1002109

Digital Measurement of Myelofibrosis Associated Platelet Derived Growth Factor Receptor ß (PDGFR ß) Expression in Bone Marrow Biopsies

Szilvia Szeghalmy ; Department of Computer Graphics and Image Processing, University of Debrecen, Hungary
Judit Bedekovics ; Department of Pathology, University of Debrecen, Hungary
Gábor Méhes ; Department of Pathology, University of Debrecen, Hungary
Attila Fazekas ; Department of Computer Graphics and Image Processing, University of Debrecen, Hungary

Puni tekst: engleski, pdf (2 MB) str. 47-56 preuzimanja: 195* citiraj
APA 6th Edition
Szeghalmy, S., Bedekovics, J., Méhes, G. i Fazekas, A. (2013). Digital Measurement of Myelofibrosis Associated Platelet Derived Growth Factor Receptor ß (PDGFR ß) Expression in Bone Marrow Biopsies. Journal of computing and information technology, 21 (1), 47-56. https://doi.org/10.2498/cit.1002109
MLA 8th Edition
Szeghalmy, Szilvia, et al. "Digital Measurement of Myelofibrosis Associated Platelet Derived Growth Factor Receptor ß (PDGFR ß) Expression in Bone Marrow Biopsies." Journal of computing and information technology, vol. 21, br. 1, 2013, str. 47-56. https://doi.org/10.2498/cit.1002109. Citirano 20.09.2019.
Chicago 17th Edition
Szeghalmy, Szilvia, Judit Bedekovics, Gábor Méhes i Attila Fazekas. "Digital Measurement of Myelofibrosis Associated Platelet Derived Growth Factor Receptor ß (PDGFR ß) Expression in Bone Marrow Biopsies." Journal of computing and information technology 21, br. 1 (2013): 47-56. https://doi.org/10.2498/cit.1002109
Harvard
Szeghalmy, S., et al. (2013). 'Digital Measurement of Myelofibrosis Associated Platelet Derived Growth Factor Receptor ß (PDGFR ß) Expression in Bone Marrow Biopsies', Journal of computing and information technology, 21(1), str. 47-56. https://doi.org/10.2498/cit.1002109
Vancouver
Szeghalmy S, Bedekovics J, Méhes G, Fazekas A. Digital Measurement of Myelofibrosis Associated Platelet Derived Growth Factor Receptor ß (PDGFR ß) Expression in Bone Marrow Biopsies. Journal of computing and information technology [Internet]. 2013 [pristupljeno 20.09.2019.];21(1):47-56. https://doi.org/10.2498/cit.1002109
IEEE
S. Szeghalmy, J. Bedekovics, G. Méhes i A. Fazekas, "Digital Measurement of Myelofibrosis Associated Platelet Derived Growth Factor Receptor ß (PDGFR ß) Expression in Bone Marrow Biopsies", Journal of computing and information technology, vol.21, br. 1, str. 47-56, 2013. [Online]. https://doi.org/10.2498/cit.1002109

Sažetak

In daily routine the reticulin silver staining is used on bone marrow biopsy samples as a gold standard for the characterization of myelofibrosis, however this method does not provide information about the prefibrotic stage.

Recently a specific immunohistochemical method was introduced which may overcome these weaknesses of reticulin staining. Activated fibroblasts responsible for stromal proliferation are highlighted by increased PDGFR β expression, which can be presented by immunohistochemistry in bone marrow samples. Using this staining the pre-fibrotic stage can become detectable and we have information about the disease activity.

During development of new staining method it is important to prove its reliability and usability. In this paper we introduce a digital image processing method to measure paranchymal damage in digitalized histological slides that can aid correct interpretation of the staining.

Ključne riječi
myelofibrosis; pdgfr; image processing

Hrčak ID: 103378

URI
https://hrcak.srce.hr/103378

Posjeta: 292 *