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https://doi.org/10.2478/10004-1254-64-2013-2290

Percutaneous Toxicity and Decontamination of Soman, VX, and Paraoxon in Rats Using Detergents

Jan Misík ; Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic
Růžena Pavliková ; Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic
Jiří Cabal ; Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic
Kamil Kuča ; Faculty of Military Health Sciences, University of Defence1, University Hospital2, Hradec Kralove, Czech Republic

Puni tekst: engleski, pdf (79 KB) str. 211-216 preuzimanja: 808* citiraj
APA 6th Edition
Misík, J., Pavliková, R., Cabal, J. i Kuča, K. (2013). Percutaneous Toxicity and Decontamination of Soman, VX, and Paraoxon in Rats Using Detergents. Arhiv za higijenu rada i toksikologiju, 64 (2), 211-216. https://doi.org/10.2478/10004-1254-64-2013-2290
MLA 8th Edition
Misík, Jan, et al. "Percutaneous Toxicity and Decontamination of Soman, VX, and Paraoxon in Rats Using Detergents." Arhiv za higijenu rada i toksikologiju, vol. 64, br. 2, 2013, str. 211-216. https://doi.org/10.2478/10004-1254-64-2013-2290. Citirano 25.09.2020.
Chicago 17th Edition
Misík, Jan, Růžena Pavliková, Jiří Cabal i Kamil Kuča. "Percutaneous Toxicity and Decontamination of Soman, VX, and Paraoxon in Rats Using Detergents." Arhiv za higijenu rada i toksikologiju 64, br. 2 (2013): 211-216. https://doi.org/10.2478/10004-1254-64-2013-2290
Harvard
Misík, J., et al. (2013). 'Percutaneous Toxicity and Decontamination of Soman, VX, and Paraoxon in Rats Using Detergents', Arhiv za higijenu rada i toksikologiju, 64(2), str. 211-216. https://doi.org/10.2478/10004-1254-64-2013-2290
Vancouver
Misík J, Pavliková R, Cabal J, Kuča K. Percutaneous Toxicity and Decontamination of Soman, VX, and Paraoxon in Rats Using Detergents. Arh Hig Rada Toksikol. [Internet]. 2013 [pristupljeno 25.09.2020.];64(2):211-216. https://doi.org/10.2478/10004-1254-64-2013-2290
IEEE
J. Misík, R. Pavliková, J. Cabal i K. Kuča, "Percutaneous Toxicity and Decontamination of Soman, VX, and Paraoxon in Rats Using Detergents", Arhiv za higijenu rada i toksikologiju, vol.64, br. 2, str. 211-216, 2013. [Online]. https://doi.org/10.2478/10004-1254-64-2013-2290

Sažetak
Highly toxic organophosphorus compounds (OPs) were originally developed for warfare or as agricultural pesticides. Today, OPs represent a serious threat to military personnel and civilians. This study investigates the in vivo decontamination of male Wistar rats percutaneously exposed to paraoxon and two potent nerve agents - soman (GD) and VX. Four commercial detergents were tested as decontaminants – NeodekontTM, ArgosTM, DermogelTM, and FloraFreeTM. Decontamination performed 2 min after exposure resulted in a higher survival rate in comparison with non-decontaminated controls. The decontamination effectiveness was expressed as protective ratio (PR, median lethal dose of agent in decontaminated animals divided by the median lethal dose of agent in untreated animals). The highest decontamination effectiveness was consistently achieved with ArgosTM (PR=2.3 to 64.8), followed by DermogelTM (PR=2.4 to 46.1). NeodekontTM and FloraFreeTM provided the lowest decontamination effectiveness, equivalent to distilled water (PR=1.0 to 43.2).

Ključne riječi
ArgosTM; chemical warfare agent; DermogelTM; FloraFreeTM; mass decontamination; military toxicology; NeodekontTM; protective ratio

Hrčak ID: 103927

URI
https://hrcak.srce.hr/103927

[hrvatski]

Posjeta: 1.111 *