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https://doi.org/10.2478/10004-1254-64-2013-2260

Protective Effect of Aerobic Exercise against L-NAME-Induced Kidney Damage in Rats

Maghsoud Peeri ; Department of Exercise Physiology, Islamic Azad University, Central Tehran Branch, Tehran, Iran
Masoumeh Habibian ; Department of Exercise Physiology, Islamic Azad University, Central Tehran Branch, Tehran, Iran
Mohammad Ali Azarbayjani ; Department of Exercise Physiology, Islamic Azad University, Central Tehran Branch, Tehran, Iran
Mehdi Hedayati ; Obesity Research Center Research Institute for Endocrine Sciences, Faculty of Shahid Beheshti University of Medical Sciences, Tehran, Iran

Puni tekst: engleski, pdf (138 KB) str. 229-234 preuzimanja: 622* citiraj
APA 6th Edition
Peeri, M., Habibian, M., Azarbayjani, M.A. i Hedayati, M. (2013). Protective Effect of Aerobic Exercise against L-NAME-Induced Kidney Damage in Rats. Arhiv za higijenu rada i toksikologiju, 64 (2), 229-234. https://doi.org/10.2478/10004-1254-64-2013-2260
MLA 8th Edition
Peeri, Maghsoud, et al. "Protective Effect of Aerobic Exercise against L-NAME-Induced Kidney Damage in Rats." Arhiv za higijenu rada i toksikologiju, vol. 64, br. 2, 2013, str. 229-234. https://doi.org/10.2478/10004-1254-64-2013-2260. Citirano 25.09.2020.
Chicago 17th Edition
Peeri, Maghsoud, Masoumeh Habibian, Mohammad Ali Azarbayjani i Mehdi Hedayati. "Protective Effect of Aerobic Exercise against L-NAME-Induced Kidney Damage in Rats." Arhiv za higijenu rada i toksikologiju 64, br. 2 (2013): 229-234. https://doi.org/10.2478/10004-1254-64-2013-2260
Harvard
Peeri, M., et al. (2013). 'Protective Effect of Aerobic Exercise against L-NAME-Induced Kidney Damage in Rats', Arhiv za higijenu rada i toksikologiju, 64(2), str. 229-234. https://doi.org/10.2478/10004-1254-64-2013-2260
Vancouver
Peeri M, Habibian M, Azarbayjani MA, Hedayati M. Protective Effect of Aerobic Exercise against L-NAME-Induced Kidney Damage in Rats. Arh Hig Rada Toksikol. [Internet]. 2013 [pristupljeno 25.09.2020.];64(2):229-234. https://doi.org/10.2478/10004-1254-64-2013-2260
IEEE
M. Peeri, M. Habibian, M.A. Azarbayjani i M. Hedayati, "Protective Effect of Aerobic Exercise against L-NAME-Induced Kidney Damage in Rats", Arhiv za higijenu rada i toksikologiju, vol.64, br. 2, str. 229-234, 2013. [Online]. https://doi.org/10.2478/10004-1254-64-2013-2260

Sažetak
Exercise, alone or combined with changes in lifestyle, can prevent or reduce the need for pharmacotherapy in patients with compromised endothelium-dependent function. The aim of this study was to examine the protective effect of aerobic exercise against (L-NAME)-kidney damage in male rats induced by Nω-nitro- L-arginine methyl ester (L-NAME). L-NAME was administered to rats intraperitoneally in doses of 10 mg kg-1 six days a week over eight weeks. Rats exercised by running on a treadmill at the speed of (15 to 22) m min-1, 25 min to 64 min per day, five days a week over eight weeks. The rats were killed 48 h after the last dose, and their kidneys removed and homogenised to measure the levels of heat shock protein70 (HSP70), superoxide dismutase activity (SOD), and thiobarbituric acid reactive substances (TBARS). We also measured serum nitrite/nitrate. Chronic administration of L-NAME significantly increased renal HSP70 and TBARS levels and decreased renal SOD activity and serum nitrites/nitrates. Training modified abnormal renal HSP70, lowered TBARS, and increased SOD and serum nitrite/nitrate. Our results have confirmed that regular aerobic exercise protects against nitric oxide deficiency-induced kidney damage by modifying HSP70, up-regulating SOD activity, and depleting TBARS.

Ključne riječi
heat shock protein70; nitric oxide; renal injury; superoxide dismutase

Hrčak ID: 103929

URI
https://hrcak.srce.hr/103929

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