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NEW INSIGHTS IN STEROID DIABETES

TINA TIČINOVIĆ KURIR ; Split University Hospital Center, Department of Clinical Pathophysiology, Split, Croatia
JOŠKO BOŽIĆ ; University of Split School of Medicine, Department of Integrative Physiology, Split, Croatia
ANITA MARKOTIĆ ; University of Split School of Medicine, Department of Medical Chemistry and Biochemistry and, Split, Croatia
ANELA NOVAK ; Split University Hospital Center, Department of Internal Medicine, Split, Croatia

Puni tekst: hrvatski, pdf (211 KB) str. 303-310 preuzimanja: 889* citiraj
APA 6th Edition
TIČINOVIĆ KURIR, T., BOŽIĆ, J., MARKOTIĆ, A. i NOVAK, A. (2012). NOVE SPOZNAJE O STEROIDNOM DIJABETESU. Acta medica Croatica, 66 (4), 303-310. Preuzeto s https://hrcak.srce.hr/104099
MLA 8th Edition
TIČINOVIĆ KURIR, TINA, et al. "NOVE SPOZNAJE O STEROIDNOM DIJABETESU." Acta medica Croatica, vol. 66, br. 4, 2012, str. 303-310. https://hrcak.srce.hr/104099. Citirano 13.12.2019.
Chicago 17th Edition
TIČINOVIĆ KURIR, TINA, JOŠKO BOŽIĆ, ANITA MARKOTIĆ i ANELA NOVAK. "NOVE SPOZNAJE O STEROIDNOM DIJABETESU." Acta medica Croatica 66, br. 4 (2012): 303-310. https://hrcak.srce.hr/104099
Harvard
TIČINOVIĆ KURIR, T., et al. (2012). 'NOVE SPOZNAJE O STEROIDNOM DIJABETESU', Acta medica Croatica, 66(4), str. 303-310. Preuzeto s: https://hrcak.srce.hr/104099 (Datum pristupa: 13.12.2019.)
Vancouver
TIČINOVIĆ KURIR T, BOŽIĆ J, MARKOTIĆ A, NOVAK A. NOVE SPOZNAJE O STEROIDNOM DIJABETESU. Acta medica Croatica [Internet]. 2012 [pristupljeno 13.12.2019.];66(4):303-310. Dostupno na: https://hrcak.srce.hr/104099
IEEE
T. TIČINOVIĆ KURIR, J. BOŽIĆ, A. MARKOTIĆ i A. NOVAK, "NOVE SPOZNAJE O STEROIDNOM DIJABETESU", Acta medica Croatica, vol.66, br. 4, str. 303-310, 2012. [Online]. Dostupno na: https://hrcak.srce.hr/104099. [Citirano: 13.12.2019.]

Sažetak
Glucocorticoids (GC) are the cornerstone in the treatment of numerous chronic autoimmune and inflammatory diseases. GC treatment is accompanied by significant metabolic adverse effects, including insulin resistance, glucose intolerance and diabetes, visceral adiposity, dyslipidemia and skeletal muscle atrophy. GCs are the most common cause of drug-induced diabetes mellitus. However, not everyone treated with glucocorticoids develops diabetes. Predictors of development of diabetes are age, weight, family history of diabetes mellitus, or personal history of gestational diabetes. There is evidence that patients with decreased insulin secretory reserve are much more likely to develop diabetes. Diabetes from topical steroid use is uncommon, but high-dose steroids have been associated with significant hyperglycemia, including development of hyperglycemic hyperosmolar syndrome and even diabetic ketoacidosis in patients with type 1 diabetes mellitus. Several mechanisms contribute to the development of hyperglycemia and steroid-induced diabetes, including decreased peripheral insulin sensitivity, increased hepatic glucose production, and inhibition of pancreatic insulin production and secretion. Physicians treating patients with GCs should be aware of the induction of metabolic disturbances and should not solely rely on fasting measurements. In addition, our review indicates that insulin therapy could be considered when treating patients on GC therapy.

Ključne riječi
glukokortikoidi; steroidni dijabetes; hiperglikemija; inzulinska rezistencija

Hrčak ID: 104099

URI
https://hrcak.srce.hr/104099

[hrvatski]

Posjeta: 1.415 *