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Preliminary Report of Hypoglycemic Response in Obese Metabolic Syndrome Males Treated with Metformin after Weight Loss Intervention

Sanda Tešanović ; Dubrovnik General Hospital, Department of Endocrinology, Dubrovnik, Croatia
Maja Radman ; University of Split, Split University Hospital Center, Department of Gastroenterology, Split, Croatia
Deša Tešanović ; University of Zagreb, School of Medicine, Zagreb, Croatia
Dubravka Jurišić Eržen ; University of Rijeka, Rijeka University Hospital Center, Department of Endocrinology, Rijeka, Croatia
Izet Hozo ; University of Split, Split University Hospital Center, Department of Gastroenterology, Split, Croatia

Puni tekst: engleski, pdf (400 KB) str. 367-371 preuzimanja: 295* citiraj
APA 6th Edition
Tešanović, S., Radman, M., Tešanović, D., Jurišić Eržen, D. i Hozo, I. (2013). Preliminary Report of Hypoglycemic Response in Obese Metabolic Syndrome Males Treated with Metformin after Weight Loss Intervention. Collegium antropologicum, 37 (2), 367-371. Preuzeto s https://hrcak.srce.hr/104462
MLA 8th Edition
Tešanović, Sanda, et al. "Preliminary Report of Hypoglycemic Response in Obese Metabolic Syndrome Males Treated with Metformin after Weight Loss Intervention." Collegium antropologicum, vol. 37, br. 2, 2013, str. 367-371. https://hrcak.srce.hr/104462. Citirano 21.10.2021.
Chicago 17th Edition
Tešanović, Sanda, Maja Radman, Deša Tešanović, Dubravka Jurišić Eržen i Izet Hozo. "Preliminary Report of Hypoglycemic Response in Obese Metabolic Syndrome Males Treated with Metformin after Weight Loss Intervention." Collegium antropologicum 37, br. 2 (2013): 367-371. https://hrcak.srce.hr/104462
Harvard
Tešanović, S., et al. (2013). 'Preliminary Report of Hypoglycemic Response in Obese Metabolic Syndrome Males Treated with Metformin after Weight Loss Intervention', Collegium antropologicum, 37(2), str. 367-371. Preuzeto s: https://hrcak.srce.hr/104462 (Datum pristupa: 21.10.2021.)
Vancouver
Tešanović S, Radman M, Tešanović D, Jurišić Eržen D, Hozo I. Preliminary Report of Hypoglycemic Response in Obese Metabolic Syndrome Males Treated with Metformin after Weight Loss Intervention. Collegium antropologicum [Internet]. 2013 [pristupljeno 21.10.2021.];37(2):367-371. Dostupno na: https://hrcak.srce.hr/104462
IEEE
S. Tešanović, M. Radman, D. Tešanović, D. Jurišić Eržen i I. Hozo, "Preliminary Report of Hypoglycemic Response in Obese Metabolic Syndrome Males Treated with Metformin after Weight Loss Intervention", Collegium antropologicum, vol.37, br. 2, str. 367-371, 2013. [Online]. Dostupno na: https://hrcak.srce.hr/104462. [Citirano: 21.10.2021.]

Sažetak
We conducted this study to determine the degree of obesity influence on the hypoglycemic response of growth hormone and cortisol after weight loss of 5%. A total of 45 non-diabetic, male subjects followed in the outpatient endocrinological departments were divided into three groups comprising 15 subjects in each group, based upon body mass index (BMI) to healthy, overweight and obese group. Metformin was administered in the dose of 50 mg daily to the overweight and obese participants. Cortisol was measured at 0, 60 and 120 minutes. Growth hormone (GH) was measured at –15, 0, 30, 60, 90 and 120 minutes.Values of cortisol and GH were compared upon changes in hypothalamo-pituitary-adrenal (HPA) response to insulin induced hypoglycemia initially and after weight loss of 5% for overweight and obese participants.The BMI of the healthy group ranged 20.0–24.5 kg/m2 (median: 22.8); overweight group ranged 25.9–29.7 kg/m2 (median: 28.3); and obese group ranged 30.9–34.6 kg/m2 (median: 32.6). There were no significant differencesof cortisol values among groups at 0 (c²=2.0; p=0.365); 60 (c²=0.754; P=0.686) and at 120 minutes (c²=0.466; p=0.792). The comparisons among groups were significant for differences of GH values at –15 (c²=25.0; p<0.01); 0 (c²=16.2; p<0.01); 30 (c²=16.2; p<0.01); 60 (c²=32.8; p<0.01); 90 (c²=30.2; p<0.01) and at 120 minutes (c²=27.3; p<0.01).Healthy and obese subjects significantly differed in growth hormone response at –15 (Z=4.67; p<0.01); 0 (Z=3.83; p<0.01); 60 (Z=2.78; p=0.05); 90 (Z=4.67; p<0.01) and at 120 minutes (Z=4.23; p<0.01).Changes on the various levels of HPA axis, when it is activated by a stress as it is the case in insulin-induced hypoglycemia correspond to the degree of obesity. Weight loss of 5% was not enough for restoration of a normal stimulated growth hormone release and did not influence on the level of cortisol.

Ključne riječi
obesity; cortisol; growth hormone

Hrčak ID: 104462

URI
https://hrcak.srce.hr/104462

Posjeta: 717 *