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Collegium antropologicum, Vol.37 No.2 Srpanj 2013.

Izvorni znanstveni članak

Hyperfiltration in Normoalbuminuric Type 1 Diabetic Patients: Relationship with Urinary Albumin Excretion Rate

Tomislav Bulum   ORCID icon orcid.org/0000-0003-4808-2968 ; University of Zagreb, School of Medicine, »Merkur« University Hospital, »Vuk Vrhovac« Clinic for Diabetes, Endocrinology and
Branko Kolarić ; University of Rijeka, School of Medicine, Rijeka, Croatia
Ingrid Prkačin ; University of Zagreb, School of Medicine, »Merkur« University Hospital, Department of Nephrology, Zagreb, Croatia
Lea Duvnjak ; University of Zagreb, School of Medicine, »Merkur« University Hospital, »Vuk Vrhovac« Clinic for Diabetes, Endocrinology and

Puni tekst: engleski, pdf (110 KB) str. 471-476 preuzimanja: 175* citiraj
APA 6th Edition
Bulum, T., Kolarić, B., Prkačin, I. i Duvnjak, L. (2013). Hyperfiltration in Normoalbuminuric Type 1 Diabetic Patients: Relationship with Urinary Albumin Excretion Rate. Collegium antropologicum, 37 (2), 471-476. Preuzeto s https://hrcak.srce.hr/104485
MLA 8th Edition
Bulum, Tomislav, et al. "Hyperfiltration in Normoalbuminuric Type 1 Diabetic Patients: Relationship with Urinary Albumin Excretion Rate." Collegium antropologicum, vol. 37, br. 2, 2013, str. 471-476. https://hrcak.srce.hr/104485. Citirano 16.11.2018.
Chicago 17th Edition
Bulum, Tomislav, Branko Kolarić, Ingrid Prkačin i Lea Duvnjak. "Hyperfiltration in Normoalbuminuric Type 1 Diabetic Patients: Relationship with Urinary Albumin Excretion Rate." Collegium antropologicum 37, br. 2 (2013): 471-476. https://hrcak.srce.hr/104485
Harvard
Bulum, T., et al. (2013). 'Hyperfiltration in Normoalbuminuric Type 1 Diabetic Patients: Relationship with Urinary Albumin Excretion Rate', Collegium antropologicum, 37(2), str. 471-476. Preuzeto s: https://hrcak.srce.hr/104485 (Datum pristupa: 16.11.2018.)
Vancouver
Bulum T, Kolarić B, Prkačin I, Duvnjak L. Hyperfiltration in Normoalbuminuric Type 1 Diabetic Patients: Relationship with Urinary Albumin Excretion Rate. Collegium antropologicum [Internet]. 2013 [pristupljeno 16.11.2018.];37(2):471-476. Dostupno na: https://hrcak.srce.hr/104485
IEEE
T. Bulum, B. Kolarić, I. Prkačin i L. Duvnjak, "Hyperfiltration in Normoalbuminuric Type 1 Diabetic Patients: Relationship with Urinary Albumin Excretion Rate", Collegium antropologicum, vol.37, br. 2, str. 471-476, 2013. [Online]. Dostupno na: https://hrcak.srce.hr/104485. [Citirano: 16.11.2018.]

Sažetak
Hyperfiltration has been documented in type 1 diabetes and may contribute to the high risk for development of albuminuria and progression of nephropathy. However, recent studies suggest that the risk of progression to albuminuria in type 1 diabetes was not increased by hyperfiltration. We investigated associations of estimated glomerular filtration rate (eGFR) and urinary albumin excretion rate (UAE) in normoalbuminuric type 1 diabetic patients. Study included 313 normoalbuminuric patients with type 1 diabetes, none showed signs of adrenal, renal, or cardiovascular diseases. GFR
was estimated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula. Glomerular hyperfiltration was defined as eGFR ³ 125 mL min–1 1.73 m–2. Renal hyperfiltration was present in 12% of the study group. Subjects with eGFR ³ 125 mL min–1 1.73 m–2 were younger, had shorter duration of diabetes, lower levels of total and LDL cholesterol, and higher HbA1c than subjects with an eGFR below 125 mL min–1 1.73 m–2. Type 1 diabetic patients
with hyperfiltration also had significantly lower UAE. In a multiple logistic regression analysis, higher eGFR was associated with lower UAE. Our results indicate that normoalbuminuric type 1 diabetic patients with hyperfiltration have lower UAE than those with renal function in the normal range. Together with other recent studies this may suggest that creatinine-based estimates of GFR indicating hyperfiltration is not associated with higher UAE and subsequent development of microalbuminuria.

Ključne riječi
glomerular filtration rate; hyperfiltration; normoalbuminuria; type 1 diabetes

Hrčak ID: 104485

URI
https://hrcak.srce.hr/104485

Posjeta: 278 *