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The 100th Anniversary of X-Ray Crystallography

B. Kojić-Prodić
K. Molčanov ; Institut Ruđer Bošković, Zagreb, Hrvatska


Puni tekst: hrvatski pdf 3.514 Kb

str. 247-260

preuzimanja: 641

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Sažetak

The important thing in science is not so much to obtain new facts as to discover new ways of thinking about them.
W. L. Bragg

The 100th anniversary of X-ray crystallography dates back to the first X-ray diffraction experiment on a crystal of copper sulphate pentahydrate. Max von Laue designed the theoretical background of the experiment, which was performed by German physicists W. Friedrich and P. Knipping in 1912. At that time, the mathematical formulation of the phenomenon and the fundamental concepts of crystallography were subjects of mineralogy. Altogether, they facilitated the development of methods for determination of the structure of matter at the atomic level. In 1913, father and son Bragg started to develop X-ray structure analysis for determination of crystal structures of simple molecules. Historic examples of structure determination starting from rock salt to complex, biologically important (macro)molecules, such as globular proteins haemoglobin and myoglobin, DNA, vitamin B12 and the recent discovery of ribozyme, illustrate the development of X-ray structural analysis. The determination of 3D structures of these molecules by X-ray diffraction had opened new areas of scientific research, such as molecular biophysics, molecular genetics, structural molecular biology, bioinorganic chemistry, organometallic chemistry, and many others. The discovery and development of X-ray crystallography revolutionised our understanding of natural sciences – physics, chemistry, biology, and also science of materials. The scientific community recognised these fundamental achievements (including the discovery of X-rays) by awarding twenty-eight Nobel prizes to thirty-nine men and two women. The explosive growth of science and technology in the 20th and 21st centuries had been founded on the detailed knowledge of the three-dimensional structure of molecules, which was the basis for explaining and predicting the physical, chemical, biological and pharmacological properties of molecules. A most recent and striking example is the still unfinished story of graphenes, occupying the front pages of leading scientific journals, such as Science, Nature, Nature Materials, Nature Nanotechnology, Nature Chemistry and Nature Physics. Contemporary crystallographic research covers numerous scientific domains, and it is a very innovative area of science. Who would dare to be a prophet and foresee future findings?

Ključne riječi

X-ray diffraction; crystallography; chemical bonds; biosciences; chemistry of materials; history of chemistry

Hrčak ID:

105196

URI

https://hrcak.srce.hr/105196

Datum izdavanja:

8.7.2013.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.754 *