Pregledni rad

PATHO-GENETICS OF POSTTRAUMATIC STRESS DISORDER

Katharina Domschke ; Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany

Sažetak

Clinical genetic studies propose a moderate genetic contribution to the pathogenesis of PTSD with a heritability of about 30-
35%. The present brief review will give an overview of molecular genetic research in PTSD yielding support for specific
vulnerability genes. Additionally, evidence for gene-environment (GxE) interactions between susceptibility genes of PTSD and
traumatic experiences will be reported. Recent studies suggest a pivotal role of epigenetic mechanisms such as DNA methylation in
mediating the impact of trauma in the pathogenesis of PTSD. Future approaches to further unravel the genetic underpinnings of
PTSD might comprise genome-wide association studies (GWAS), the investigation of the genetic influence on intermediate
phenotypes of PTSD (e.g., imaging genetics) as well as pharmaco- and psychotherapy-genetic studies. Genetic research in PTSD will
be discussed with respect to its potential benefit regarding innovative and individually tailored therapeutic approaches in PTSD.

Ključne riječi

PTSD; association; gene-environment interaction; epigenetics; imaging genetics; pharmacogenetics

Hrčak ID:

106235

URI

https://hrcak.srce.hr/106235

Datum izdavanja:

24.9.2012.

Posjeta: 1.015 *