hrcak mascot   Srce   HID

Pregledni rad

Cervical cancer and DNA methylation

Nina Milutin Gašperov
Magdalena Grce

Puni tekst: hrvatski, pdf (444 KB) str. 234-239 preuzimanja: 345* citiraj
APA 6th Edition
Milutin Gašperov, N. i Grce, M. (2013). Rak vrata maternice i metiliranje DNK. Medix, 19 (104/105), 234-239. Preuzeto s
MLA 8th Edition
Milutin Gašperov, Nina i Magdalena Grce. "Rak vrata maternice i metiliranje DNK." Medix, vol. 19, br. 104/105, 2013, str. 234-239. Citirano 22.09.2021.
Chicago 17th Edition
Milutin Gašperov, Nina i Magdalena Grce. "Rak vrata maternice i metiliranje DNK." Medix 19, br. 104/105 (2013): 234-239.
Milutin Gašperov, N., i Grce, M. (2013). 'Rak vrata maternice i metiliranje DNK', Medix, 19(104/105), str. 234-239. Preuzeto s: (Datum pristupa: 22.09.2021.)
Milutin Gašperov N, Grce M. Rak vrata maternice i metiliranje DNK. Medix [Internet]. 2013 [pristupljeno 22.09.2021.];19(104/105):234-239. Dostupno na:
N. Milutin Gašperov i M. Grce, "Rak vrata maternice i metiliranje DNK", Medix, vol.19, br. 104/105, str. 234-239, 2013. [Online]. Dostupno na: [Citirano: 22.09.2021.]

Cervical cancer develops gradually over many years through several stages ranging from cervical intraepithelial neoplasia to invasive cancer. The progression of cervical precancerous lesions essentially depends on the presence of persistent infection with oncogenic types of human papillomavirus. In addition, epigenetic events play a significant role in the development and progression of cancer in general. Epigenetic changes, such as DNA methylation in the promoter region of genes where transcription is initiated, results in inactivation and silencing of many genes. Transcriptional silencing through DNA methylation of critical growth regulators and tumour suppressor genes plays a major role in cancer. This deregulated epigenetic event in cancer can be reversed by DNA methylation inhibitors. In cervical cancer, altered DNA methylation is described for more than 200 genes, including tumour suppressor genes, representing potential biomarkers of cervical lesions. However, for now, change in methylation of any of the described gene does not fully meet the criteria of sufficient sensitivity and specificity for population screening.

Ključne riječi
cervical intraepithelial neoplasm; epigenetics; human papillomavirus; uterine cervical neoplasms

Hrčak ID: 106600



Posjeta: 630 *