Ostalo
Comparison of the efficacy of topical minoxidil 5% and adenosine 0.75% solutions on male androgenetic alopecia and measuring the patients' satisfactory rate
Gita Faghihi
; 1-Skin Disease and Leishmaniasis Research Center (Sedigheh Tahereh), Isfahan University of Medical Sciences, Isfahan, Iran 2-Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran
Fariba Iraji
; 1-Skin Disease and Leishmaniasis Research Center (Sedigheh Tahereh), Isfahan University of Medical Sciences, Isfahan, Iran 2-Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran
manijeh Rajaee Harandi
; Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran
gholamreza askari
; -Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran -Skin Disease and Leishmaniasis Research Center (Sedigheh Tahereh), Isfahan University of Medical Sciences, Isfahan, Iran
Sažetak
Objective: According to the hypothesis regarding the stimulating effect of adenosine on increasing fibroblast growth factor-7 in dermal papilla cells and its vasorelaxant effect, we performed this study to compare the effect of topical minoxidil 5% and adenosine 0.75% on male pattern androgenic alopecia. Methods and materials: This prospective-randomized study recruited 110 male patients, who suffered from grade II-V Hamilton androgenic alopecia. Fifty-five patients received minoxidil 5% (group-1) and others received adenosine 0.75% (group-2). Later, 16 patients excluded due to allergic reactions or loss to follow-up. After 3 and 6 months of treatment, complete and relative recovery rates alongside patients' satisfactory rate (faster prevention of primary hair loss and appearance of newly grown hair) were compared between groups. Results: After 3 months of treatment, relative recovery was achieved in 2.4% and 1.9% of patients in group-1 and group-2, which was not significantly different (p-value= 0.17). During 6 months, relative recovery rate did not change nighter within nor between the groups (p-value =0.99) and after 6 months none of the patients achieved complete recovery. However, the patients' satisfactory rate was significantly higher in the group-2 (p-value =0.003). Conclusion: In light of the results, adenosine has no statistically superiority to minoxidil on treatment of androgenic alopecia according to the recovery rates. However, the patients were significantly more satisfied with the adenosine because of the faster prevention of hair loss and appearance of the newly grown hairs. It seems further studies with larger sample size or different drug dosages are required to clarify the findings.
Ključne riječi
Androgenetic alopecia; Adenosine; Minoxidil 5%
Hrčak ID:
109921
URI
Datum izdavanja:
29.10.2013.
Posjeta: 5.389 *