Izvorni znanstveni članak
Correlation between mean platelet volume and total risk of cardiovascular disease
DAMIR FABIJANIĆ
orcid.org/0000-0002-4199-3905
; Department of Internal Medicine, University Hospital Split, Spincicieva 1, 21000 Split, Croatia
VEDRAN CAREVIĆ
orcid.org/0000-0002-0009-5009
; Department of Internal Medicine, University Hospital Split, Spincicieva 1, 21000 Split, Croatia
DAMIR BONACIN
; Department of Internal Medicine, University Hospital Split, Spincicieva 1, 21000 Split, Croatia
DOMAGOJ MARKOVIĆ
; Traffic Technical School, Split, Croatia
BRANKA PAUKOVIĆ SEKULIĆ
; Department of Biochemistry and Laboratory medicine, University Hospital Split, Split, Croatia
ADA SAPUNAR
; Department of Biochemistry and Laboratory medicine, University Hospital Split, Split, Croatia
Sažetak
Introduction. The association between mean platelet volume (MPV) and single cardiovascular disease (CVD) risk factors has previously been tested. The aim of our study was to evaluate the association between MPV and total risk of CVD. Materials and Methods. In 216 consecutive outpatients referred for a cardiology assessment because of multiple CVD risk factors, total CVD risk was estimated according to the Framingham Risk Score (FRS) as low (<10%), intermediate (11-19%), and high (>20%). Additionally, FRS was adjusted for triglycerides (TG), body mass index (BMI) and a family history of CVD, important CVD risk factors which are not included in the FRS equation. Also, CVD risk was estimated according to terciles of MPV (<8.3, 8.3-9.1, >9.1 fL, respectively). Correlation between high sensitivity C-reactive protein (hs-CRP) and FRS was used as confirmation that our study hypothesis was properly set. Results. MPV did not correlate with individual CVD risk factors or with FRS, either before, or after adjustment for additional CVD risk factors. Significant correlation between MPV and total CV risk was observed only in the adjusted high FRS group; namely, for persons in tercile 3, CVD risk was doubled (OR 2.2; 95% CI 1.05-4.64; P =0.038). In comparison, there was a strong linear correlation between hs-CRP and unadjusted (r=0.203, P=0.004) and adjusted (r=0.383, P<0.001) FRS. Conclusion. Correlation between MPV and high total CVD risk suggests increased platelet activity primarily as a consequence and sign of atherosclerotic vascular damage. Linear correlation between hs-CRP with FRS confirms inflammation as an important mechanism of atherogenesis.
Ključne riječi
platelets; atherosclerosis; coronary risk prediction; Framingham risk score
Hrčak ID:
110341
URI
Datum izdavanja:
1.10.2013.
Posjeta: 1.010 *