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Glucocorticoid-Induced Osteoporosis

Božidar Ćurković

Puni tekst: hrvatski, pdf (62 KB) str. 19-24 preuzimanja: 1.998* citiraj
APA 6th Edition
Ćurković, B. (2007). Osteoporoza uzrokovana glukokortikoidima. Arhiv za higijenu rada i toksikologiju, 58 (1), 19-24. Preuzeto s
MLA 8th Edition
Ćurković, Božidar. "Osteoporoza uzrokovana glukokortikoidima." Arhiv za higijenu rada i toksikologiju, vol. 58, br. 1, 2007, str. 19-24. Citirano 01.10.2020.
Chicago 17th Edition
Ćurković, Božidar. "Osteoporoza uzrokovana glukokortikoidima." Arhiv za higijenu rada i toksikologiju 58, br. 1 (2007): 19-24.
Ćurković, B. (2007). 'Osteoporoza uzrokovana glukokortikoidima', Arhiv za higijenu rada i toksikologiju, 58(1), str. 19-24. Preuzeto s: (Datum pristupa: 01.10.2020.)
Ćurković B. Osteoporoza uzrokovana glukokortikoidima. Arh Hig Rada Toksikol. [Internet]. 2007 [pristupljeno 01.10.2020.];58(1):19-24. Dostupno na:
B. Ćurković, "Osteoporoza uzrokovana glukokortikoidima", Arhiv za higijenu rada i toksikologiju, vol.58, br. 1, str. 19-24, 2007. [Online]. Dostupno na: [Citirano: 01.10.2020.]

Glucocorticoids are the most common cause of drug-induced osteoporosis. Given the widespread use of oral glucocorticoids in the treatment of autoimmune, pulmonary, gastrointestinal disorders and organ transplantation, attention to glucocorticoid-induced osteoporosis has substantially increased. Bone loss occurs rapidly in the first few months of glucocorticoid therapy. Trabecular bone is affected more than cortical bone. Glucocorticoid treatment is associated with a substantially increased risk of fractures, particularly hip and vertebral fractures. The skeletal effects of glucocorticoids are both dose- and durationdependent. The patophysiology of glucocorticoid-induced osteoporosis is a complex process, several mechanisms are proposed but not yet fully highlighted. Despite several evidence-based guidelines for the prevention and treatment of glucocorticoid-induced osteoporosis and the availability of effective therapeutic options, the proportion of individuals with appropriate evaluation and treatment remains relatively low.

Ključne riječi
drug-induced osteoporosis; osteoclastogenesis; osteoporosis management; pathophysiology; risk of fractures

Hrčak ID: 10610



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