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https://doi.org/10.5562/cca2301

A Heuristic Algorithm for Plate SelectionThat Maximizes Compound Diversity

Hongyao Zhu ; Pfizer Worldwide Research and Development, Groton, Connecticut, United States
Jacquelyn Klug-McLeod ; Pfizer Worldwide Research and Development, Groton, Connecticut, United States
Gregory A. Bakken ; Pfizer Worldwide Research and Development, Groton, Connecticut, United States

Puni tekst: engleski, pdf (1 MB) str. 435-441 preuzimanja: 683* citiraj
APA 6th Edition
Zhu, H., Klug-McLeod, J. i Bakken, G.A. (2013). A Heuristic Algorithm for Plate SelectionThat Maximizes Compound Diversity. Croatica Chemica Acta, 86 (4), 435-441. https://doi.org/10.5562/cca2301
MLA 8th Edition
Zhu, Hongyao, et al. "A Heuristic Algorithm for Plate SelectionThat Maximizes Compound Diversity." Croatica Chemica Acta, vol. 86, br. 4, 2013, str. 435-441. https://doi.org/10.5562/cca2301. Citirano 08.03.2021.
Chicago 17th Edition
Zhu, Hongyao, Jacquelyn Klug-McLeod i Gregory A. Bakken. "A Heuristic Algorithm for Plate SelectionThat Maximizes Compound Diversity." Croatica Chemica Acta 86, br. 4 (2013): 435-441. https://doi.org/10.5562/cca2301
Harvard
Zhu, H., Klug-McLeod, J., i Bakken, G.A. (2013). 'A Heuristic Algorithm for Plate SelectionThat Maximizes Compound Diversity', Croatica Chemica Acta, 86(4), str. 435-441. https://doi.org/10.5562/cca2301
Vancouver
Zhu H, Klug-McLeod J, Bakken GA. A Heuristic Algorithm for Plate SelectionThat Maximizes Compound Diversity. Croatica Chemica Acta [Internet]. 2013 [pristupljeno 08.03.2021.];86(4):435-441. https://doi.org/10.5562/cca2301
IEEE
H. Zhu, J. Klug-McLeod i G.A. Bakken, "A Heuristic Algorithm for Plate SelectionThat Maximizes Compound Diversity", Croatica Chemica Acta, vol.86, br. 4, str. 435-441, 2013. [Online]. https://doi.org/10.5562/cca2301

Sažetak
A heuristic algorithm was developed to maximize compound diversity within a subset of screening
plates used in high throughput screening (HTS) to initiate the drug discovery process. The approach
overcame the challenge of combinatorial explosion for selecting plate subsets with maximum compound
diversity. The method yielded novel forms of plate-based diversity subsets (PBDS) for HTS screening in
lead discovery. The algorithm, its validation and the application to our screening collection are outlined.
(doi: 10.5562/cca2301)

Ključne riječi
high throughput screening (HTS); plate-based diverse subset (PBDS); combinatorial optimization

Hrčak ID: 112768

URI
https://hrcak.srce.hr/112768

Posjeta: 919 *