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TREATMENT GUIDELINES FOR PATIENTS WITH GENOTYPE 1 CHRONIC HEPATIS C INFECTION

ADRIANA VINCE ; Dr. Fran Mihaljević University Hospital for Infectious Diseases, Zagreb, Croatia
MARKO DUVNJAK ; Sestre milosrdnice University Hospital Center, Clinical Department of Medicine, Department of Gastroenterology, Zagreb, Croatia
IVAN KURELAC ; Dr. Fran Mihaljević University Hospital for Infectious Diseases, Zagreb, Croatia

Puni tekst: hrvatski, pdf (172 KB) str. 329-338 preuzimanja: 773* citiraj
APA 6th Edition
VINCE, A., DUVNJAK, M. i KURELAC, I. (2013). PREPORUKE ZA LIJEČENJE BOLESNIKA S KRONIČNIM HEPATITISOM C GENOTIPA 1. Acta medica Croatica, 67 (4), 329-338. Preuzeto s https://hrcak.srce.hr/113720
MLA 8th Edition
VINCE, ADRIANA, et al. "PREPORUKE ZA LIJEČENJE BOLESNIKA S KRONIČNIM HEPATITISOM C GENOTIPA 1." Acta medica Croatica, vol. 67, br. 4, 2013, str. 329-338. https://hrcak.srce.hr/113720. Citirano 04.12.2020.
Chicago 17th Edition
VINCE, ADRIANA, MARKO DUVNJAK i IVAN KURELAC. "PREPORUKE ZA LIJEČENJE BOLESNIKA S KRONIČNIM HEPATITISOM C GENOTIPA 1." Acta medica Croatica 67, br. 4 (2013): 329-338. https://hrcak.srce.hr/113720
Harvard
VINCE, A., DUVNJAK, M., i KURELAC, I. (2013). 'PREPORUKE ZA LIJEČENJE BOLESNIKA S KRONIČNIM HEPATITISOM C GENOTIPA 1', Acta medica Croatica, 67(4), str. 329-338. Preuzeto s: https://hrcak.srce.hr/113720 (Datum pristupa: 04.12.2020.)
Vancouver
VINCE A, DUVNJAK M, KURELAC I. PREPORUKE ZA LIJEČENJE BOLESNIKA S KRONIČNIM HEPATITISOM C GENOTIPA 1. Acta medica Croatica [Internet]. 2013 [pristupljeno 04.12.2020.];67(4):329-338. Dostupno na: https://hrcak.srce.hr/113720
IEEE
A. VINCE, M. DUVNJAK i I. KURELAC, "PREPORUKE ZA LIJEČENJE BOLESNIKA S KRONIČNIM HEPATITISOM C GENOTIPA 1", Acta medica Croatica, vol.67, br. 4, str. 329-338, 2013. [Online]. Dostupno na: https://hrcak.srce.hr/113720. [Citirano: 04.12.2020.]

Sažetak
Dual therapy based on the combination of pegylated interferon-alpha 2a or 2b (PEG IFN-α2) and ribavirin has been considered standard-of-care treatment for chronic hepatitis C genotype 1 up to 2011. The first generation of protease inhibitors, boceprevir and telaprevir, have been approved for clinical use in Europe and USA since 2011. Therefore, national guidelines for the treatment of chronic hepatitis C genotype 1 have been updated to include new and more efficient therapeutic options. Croatian guidelines are based on the results of registration clinical trials for boceprevir and telaprevir, national guidelines of several EU countries (United Kingdom, Sweden, Germany, France and Italy), EASL and AASLD recommendations, as well as on the results of chronic hepatitis C genotype 1 treatment with dual therapy at the national level. The Croatian guidelines include recommendations for treatment-naïve and treatment-experienced patients (based on the type of virologic response to the first-line treatment). In treatment-naïve patients with mild fibrosis and favorable predictors of treatment outcome, dual therapy is the recommended treatment option. In treatment-naïve patients with advanced fibrosis (F3 and F4) as well as in patients with moderate fibrosis (F2) and unfavorable predictors of treatment outcome (age >40 years, non-CC IL-28B genotype, non-RVR), triple therapy is recommended. Triple therapy is also recommended for relapsers (irrespective of fibrosis stage) and partial responders with advanced fibrosis (F3 and F4). Lead-in treatment strategy during triple therapy is recommended for null-responders.

Ključne riječi
chronic hepatitis C; genotype 1; treatment; boceprevir; telaprevir

Hrčak ID: 113720

URI
https://hrcak.srce.hr/113720

[hrvatski]

Posjeta: 1.059 *