Izvorni znanstveni članak

https://doi.org/10.2478/acph-2014-0013

Evaluation of chitosan based vaginal bioadhesive gel formulations for antifungal drugs

ZEYNEP AY ŞENYIĞIT ; Ege University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 35100, Bornova, İzmir, Turkey
SINEM YAPRAK KARAVANA ; Ege University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 35100, Bornova, İzmir, Turkey
BAYRI ERAÇ ; Ege University, Faculty of Pharmacy, Department of Microbiology, 35100, Bornova, İzmir, Turkey
ÖZGE GÜRSEL ; Ege University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 35100, Bornova, İzmir, Turkey
MINE HOŞGÖR LIMONCU ; Ege University, Faculty of Pharmacy, Department of Microbiology, 35100, Bornova, İzmir, Turkey
ESRA BALOĞLU ; Ege University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 35100, Bornova, İzmir, Turkey

Sažetak

The aim of the present study was to evaluate chitosan as a vaginal mucoadhesive gel base for econazole nitrate and miconazole nitrate. For this aim, different types of chitosan with different molecular massess and viscosity properties [low molecular mass chitosan (viscosity: 20.000 mPa s), medium molecular mass chitosan (viscosity: 200.000 mPa s), high molecular mass chitosan (viscosity: 800.000 mPa s)] have been used. Firstl, rheological studies were conducted on chitosan gels. Mechanical, syringeability and mucoadhesive properties of the chitosan gels were determined. The release profiles of econazole nitrate and miconazole nitrate from chitosan gels were obtained and evaluated kinetically. In addition, anticandidal activities of formulations were determined. Finally, vaginal retention of chitosan gels in rats was evaluated with in vivo distribution studies. Based on the results, it can be concluded that gels prepared with medium molecular mass chitosan might be effectively used for different antifungal agents for the treatment of vaginal candidiosis as it has high mucoadhesiveness, suitable mechanical and release properties with good retention in vagina.

Ključne riječi

chitosan; vaginal gel; mucoadhesion; econazole nitrate; miconazole nitrate; vaginal retention

Hrčak ID:

114597

URI

https://hrcak.srce.hr/114597

Datum izdavanja:

30.6.2014.

Posjeta: 3.407 *