Biochemia Medica, Vol. 24 No. 1, 2014.
Pregledni rad
https://doi.org/10.11613/BM.2014.010
Interference of medical contrast media on laboratory testing
Giuseppe Lippi
orcid.org/0000-0001-9523-9054
; Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma, Italy
Massimo Daves Daves
; Clinical Biochemical Laboratory, San Maurizio Regional Hospital, Bolzano, Italy
Camilla Mattiuzzi Mattiuzzi
; Service of Clinical Governance, General Hospital of Trento, Trento, Italy
Sažetak
The use of contrast media such as organic iodine molecules and gadolinium contrast agents is commonplace in diagnostic imaging. Although there is widespread perception that side effects and drug interactions may be the leading problems caused by these compounds, various degrees of interference with some laboratory tests have been clearly demonstrated. Overall, the described interference for iodinate contrast media include inappropriate gel barrier formation in blood tubes, the appearance of abnormal peaks in capillary zone electrophoresis of serum proteins, and a positive bias in assessment of cardiac troponin I with one immunoassay. The interference for gadolinium contrast agents include negative bias in calcium assessment with ortho-cresolphthalein colorimetric assays and occasional positive bias using some Arsenazo reagents, negative bias in measurement of angiotensin converting enzyme (ACE) and zinc (colorimetric assay), as well as positive bias in creatinine (Jaffe reaction), total iron binding capacity (TIBC, ferrozine method), magnesium (calmagite reagent) and selenium (mass spectrometry) measurement. Interference has also been reported in assessment of serum indices, pulse oximetry and methaemoglobin in samples of patients receiving Patent Blue V. Under several circumstances the interference was absent from manufacturer-supplied information and limited to certain type of reagents and/or analytes, so that local verification may be advisable to establish whether or not the test in use may be biased. Since the elimination half-life of these compounds is typically lower than 2 h, blood collection after this period may be a safer alternative in patients who have received contrast media for diagnostic purposes.
Ključne riječi
errors; analytical interference; contrast media; contrast agents; gadolinium
Hrčak ID:
115747
URI
Datum izdavanja:
15.2.2014.
Posjeta: 1.263 *