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Lifestyle, telomeres and aging – what is the connection?

NIKOLINA ŠKROBOT VIDAČEK ; Laboratory for Molecular and Cell Biology, Department of Molecular Biology, Ruđer Bošković Institute, Zagreb, Croatia
DARKO PAVLIĆ ; Laboratory for Molecular and Cell Biology, Department of Molecular Biology, Ruđer Bošković Institute, Zagreb, Croatia
MAJA PERIĆ ; Laboratory for Molecular and Cell Biology, Department of Molecular Biology, Ruđer Bošković Institute, Zagreb, Croatia
IVICA RUBELJ ; Laboratory for Molecular and Cell Biology, Department of Molecular Biology, Ruđer Bošković Institute, Bijenička cesta 54, Zagreb, Croatia

Sažetak

Telomere shortening is the mayor contributor of cellular aging and
telomere length is reliable biomarker of aging process, both at individual as well as at the population level. Short telomeres are also connected with aging related diseases like cancer, cardiovascular diseases and diabetes which are the leading causes of death in the world today. Recently, it has been demonstrated, for the first time, that comprehensive lifestyle changes can slow aging process at molecular level. Such changes include food rich in fiber, fruits and vegetables as well as low fat and low refined carbohydrates diet. If this diet is combined with moderate exercise and stress management techniques, it can result in increased telomerase activity in peripheral mononuclear blood cells during three months period only, which subsequently
slow down telomere loss in humans.

Ključne riječi

telomeres; aging; telomerase activity; telomere length; lifestyle changes; oxidative stress

Hrčak ID:

116325

URI

https://hrcak.srce.hr/116325

Datum izdavanja:

31.12.2013.

Posjeta: 1.708 *