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https://doi.org/10.2478/10004-1254-65-2014-2398

Efficiency of hepatocyte pretreatment with coenzyme Q10 against statin toxicity

Mohammad Ali Eghbal ; Drug Applied Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran
Narges Abdoli ; Biotechnology Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran
Yadollah Azarmi ; Biotechnology Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran

Puni tekst: engleski, pdf (1 MB) str. 101-107 preuzimanja: 592* citiraj
APA 6th Edition
Eghbal, M.A., Abdoli, N. i Azarmi, Y. (2014). Efficiency of hepatocyte pretreatment with coenzyme Q10 against statin toxicity. Arhiv za higijenu rada i toksikologiju, 65 (1), 101-107. https://doi.org/10.2478/10004-1254-65-2014-2398
MLA 8th Edition
Eghbal, Mohammad Ali, et al. "Efficiency of hepatocyte pretreatment with coenzyme Q10 against statin toxicity." Arhiv za higijenu rada i toksikologiju, vol. 65, br. 1, 2014, str. 101-107. https://doi.org/10.2478/10004-1254-65-2014-2398. Citirano 26.09.2020.
Chicago 17th Edition
Eghbal, Mohammad Ali, Narges Abdoli i Yadollah Azarmi. "Efficiency of hepatocyte pretreatment with coenzyme Q10 against statin toxicity." Arhiv za higijenu rada i toksikologiju 65, br. 1 (2014): 101-107. https://doi.org/10.2478/10004-1254-65-2014-2398
Harvard
Eghbal, M.A., Abdoli, N., i Azarmi, Y. (2014). 'Efficiency of hepatocyte pretreatment with coenzyme Q10 against statin toxicity', Arhiv za higijenu rada i toksikologiju, 65(1), str. 101-107. https://doi.org/10.2478/10004-1254-65-2014-2398
Vancouver
Eghbal MA, Abdoli N, Azarmi Y. Efficiency of hepatocyte pretreatment with coenzyme Q10 against statin toxicity. Arh Hig Rada Toksikol. [Internet]. 2014 [pristupljeno 26.09.2020.];65(1):101-107. https://doi.org/10.2478/10004-1254-65-2014-2398
IEEE
M.A. Eghbal, N. Abdoli i Y. Azarmi, "Efficiency of hepatocyte pretreatment with coenzyme Q10 against statin toxicity", Arhiv za higijenu rada i toksikologiju, vol.65, br. 1, str. 101-107, 2014. [Online]. https://doi.org/10.2478/10004-1254-65-2014-2398

Sažetak
Statins are potent cholesterol-lowering drugs that can have serious adverse effects on the muscles and liver. The aim of our in vitro study was to establish the protective effect of coenzyme Q10 (CoQ10, in its optimal dose of 200 μmol L-1) against cytotoxicity induced by atorvastatin, simvastatin, and lovastatin in isolated rat hepatocytes by observing parameters such as cell death, reactive oxygen species formation, lipid peroxidation, mitochondrial membrane potential, and cellular reduced and oxidised glutathione content. Our findings have shown that pretreatment with CoQ10 was effective in reducing the toxic effects of statins in rat hepatocytes. This work demonstrates that the addition of CoQ10 to statin treatment regimens may protect hepatocytes (and also other types of cells) from statin-induced injuries and alleviate their side effects.

Ključne riječi
atorvastatin; hepatotoxicity; lipid peroxidation; lovastatin; oxidative stress; reactive oxygen species; simvastatin; ubiquinone

Hrčak ID: 117135

URI
https://hrcak.srce.hr/117135

[hrvatski]

Posjeta: 953 *