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https://doi.org/10.2478/10004-1254-65-2014-2416

3-nitrotyrosine levels in dichlorvos-induced neurotoxicity

Dilek Guvenç   ORCID icon orcid.org/0000-0003-0036-0914 ; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ondokuz Mayis University, Samsun, Turkey
Abdurrahman Aksoy   ORCID icon orcid.org/0000-0001-9486-312X ; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ondokuz Mayis University, Samsun, Turkey
Yavuz Kursad Das   ORCID icon orcid.org/0000-0001-8634-5752 ; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ondokuz Mayis University, Samsun, Turkey
Enes Atmaca ; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ondokuz Mayis University, Samsun, Turkey
Oguzhan Yavuz ; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ondokuz Mayis University, Samsun, Turkey

Puni tekst: engleski, pdf (248 KB) str. 109-111 preuzimanja: 454* citiraj
APA 6th Edition
Guvenç, D., Aksoy, A., Das, Y.K., Atmaca, E. i Yavuz, O. (2014). 3-nitrotyrosine levels in dichlorvos-induced neurotoxicity. Arhiv za higijenu rada i toksikologiju, 65 (1), 109-111. https://doi.org/10.2478/10004-1254-65-2014-2416
MLA 8th Edition
Guvenç, Dilek, et al. "3-nitrotyrosine levels in dichlorvos-induced neurotoxicity." Arhiv za higijenu rada i toksikologiju, vol. 65, br. 1, 2014, str. 109-111. https://doi.org/10.2478/10004-1254-65-2014-2416. Citirano 20.09.2020.
Chicago 17th Edition
Guvenç, Dilek, Abdurrahman Aksoy, Yavuz Kursad Das, Enes Atmaca i Oguzhan Yavuz. "3-nitrotyrosine levels in dichlorvos-induced neurotoxicity." Arhiv za higijenu rada i toksikologiju 65, br. 1 (2014): 109-111. https://doi.org/10.2478/10004-1254-65-2014-2416
Harvard
Guvenç, D., et al. (2014). '3-nitrotyrosine levels in dichlorvos-induced neurotoxicity', Arhiv za higijenu rada i toksikologiju, 65(1), str. 109-111. https://doi.org/10.2478/10004-1254-65-2014-2416
Vancouver
Guvenç D, Aksoy A, Das YK, Atmaca E, Yavuz O. 3-nitrotyrosine levels in dichlorvos-induced neurotoxicity. Arh Hig Rada Toksikol. [Internet]. 2014 [pristupljeno 20.09.2020.];65(1):109-111. https://doi.org/10.2478/10004-1254-65-2014-2416
IEEE
D. Guvenç, A. Aksoy, Y.K. Das, E. Atmaca i O. Yavuz, "3-nitrotyrosine levels in dichlorvos-induced neurotoxicity", Arhiv za higijenu rada i toksikologiju, vol.65, br. 1, str. 109-111, 2014. [Online]. https://doi.org/10.2478/10004-1254-65-2014-2416

Sažetak
The aim of this study was to evaluate dichlorvos toxicity in terms of nitro-oxidative stress by determining 3-nitrotyrosine (3-NT) levels in the fore, mid, and hindbrain regions in acutely exposed rats. Male Sprague- Dawley rats were randomly allocated to three groups of eight. Group 1 was administered a single intraperitoneal dichlorvos dose of 1.8 mg kg-1 (0.1xLD50) and group 2 a dose of 9 mg kg-1 (0.5xLD50). The control group received 0.5 mL saline solution via the same route. 3-NT and tyrosine (TYR) levels were measured using high performance liquid chromatography with a photodiode array detector (HPLC-PDA) and expressed as a ratio of 3-NT to TYR. The 3-NT/1000 TYR ratios increased significantly in the fore-, mid- and hindbrains of the exposed groups compared to control (p<0.01). In the forebrain, the increase was also significant between the treated groups. Our study has confirmed that acute exposure to dichlorvos leads to nitro-oxidative stress in the brain and that 3-NT may play a role in the mechanism of dichlorvos neurotoxicity.

Ključne riječi
brain; HPLC; nitro-oxidative stress; pesticides; rats

Hrčak ID: 117136

URI
https://hrcak.srce.hr/117136

[hrvatski]

Posjeta: 697 *