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Collegium antropologicum, Vol.37 No.3 Rujan 2013.

Izvorni znanstveni članak

Total and LDL Cholesterol are Associated with Glomerular Filtration Rate in Normoalbuminuric Type 1 Diabetic Patients

Tomislav Bulum ; University of Zagreb, University Hospital Merkur, »Vuk Vrhovac« Clinic for Diabetes, Endocrinology and Metabolic Diseases, School of Medicine, Zagreb, Croatia
Branko Kolarić ; University of Rijeka, School of Medicine, Rijeka, Croatia
Ingrid Prkačin ; University of Zagreb, University Hospital Merkur, School of Medicine, Department of Internal medicine, Zagreb, Croatia
Lea Duvnjak ; University of Zagreb, University Hospital Merkur, »Vuk Vrhovac« Clinic for Diabetes, Endocrinology and Metabolic Diseases, School of Medicine, Zagreb, Croatia

Puni tekst: engleski, pdf (111 KB) str. 771-776 preuzimanja: 160* citiraj
APA 6th Edition
Bulum, T., Kolarić, B., Prkačin, I. i Duvnjak, L. (2013). Total and LDL Cholesterol are Associated with Glomerular Filtration Rate in Normoalbuminuric Type 1 Diabetic Patients. Collegium antropologicum, 37 (3), 771-776. Preuzeto s https://hrcak.srce.hr/118216
MLA 8th Edition
Bulum, Tomislav, et al. "Total and LDL Cholesterol are Associated with Glomerular Filtration Rate in Normoalbuminuric Type 1 Diabetic Patients." Collegium antropologicum, vol. 37, br. 3, 2013, str. 771-776. https://hrcak.srce.hr/118216. Citirano 18.06.2018.
Chicago 17th Edition
Bulum, Tomislav, Branko Kolarić, Ingrid Prkačin i Lea Duvnjak. "Total and LDL Cholesterol are Associated with Glomerular Filtration Rate in Normoalbuminuric Type 1 Diabetic Patients." Collegium antropologicum 37, br. 3 (2013): 771-776. https://hrcak.srce.hr/118216

Sažetak
Studies have generally suggested a positive association between dyslipidemia and chronic kidney disease, but sparse data are available on the relation of lipids and glomerular filtration rate in patients with normal renal function. We in- vestigated the associations of serum lipids, including total, LDL, HDL, VLDL cholesterol, and triglyceride levels with es- timated glomerular filtration rate (eGFR) in type 1 diabetic patients. Study included 313 normoalbuminuric type 1 diabetic patients with normal or mild decrease (eGFR > 60 mL/min per 1.73 m 2 ) renal function and before any interventions with statins, ACE inhibitors or angiotensin II receptor blockers. eGFR was significantly associated with total, LDL, and HDL cholesterol (r= –0.21, –0.18, and –0.17, respectively, for all p <0.05). Stratifying serum lipids for degree of eGFR, levels of total, LDL, and HDL cholesterol were inversely related to eGFR, but trends were significant only for total (5.1 vs 5.0 and 4.6 mmol/L) and LDL cholesterol (2.9 vs 2.8 and 2.4 mmol/L). We have detected an association between eGFR and lipid abnormalities in type 1 diabetes in early stages. The study was conducted in patients with no therapeutic inter- vention. This may suggest that lipid abnormalities may play a role in the pathogenesis of renal impairment in type 1 diabetic patients.

Ključne riječi
type 1 diabetes; serum lipids; renal function; glomerular filtration rate

Hrčak ID: 118216

URI
https://hrcak.srce.hr/118216

Posjeta: 229 *