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Interleukin-6 Polymorphism and Prostate Cancer Risk in Population of Eastern Croatia

Sanja Mandić ; »J. J. Strossmayer« University, University Hospital Centre Osijek, Department of Clinical Laboratory Diagnostics, Osijek, Croatia
Bojan Sudarević ; »J. J. Strossmayer« University, University Hospital Centre Osijek, Clinic of Urology, Osijek, Croatia
Saška Marczi ; »J. J. Strossmayer« University, University Hospital Centre Osijek, Clinical Institute of Nuclear Medicine and Radiation Protection, Department of Molecular Diagnostics and Tissue Typing, Osijek, Croatia
Vesna Horvat ; »J. J. Strossmayer« University, University Hospital Centre Osijek, Department of Clinical Laboratory Diagnostics, Osijek, Croatia
Ivan Ćosić ; »J. J. Strossmayer« University, University Hospital Centre Osijek, Clinic of Urology, Osijek, Croatia
Slobodan Mihaljević ; University of Zagreb, University Hospital Centre Zagreb, Clinic of Gynecology and Obstetrics, Department for Anaesthesiology, Zagreb, Croatia
Nevenka Miličević ; »J. J. Strossmayer« University, University Hospital Centre Osijek, Department of Anesthesiology, Reanimatology and Intensive Care Unit, Osijek, Croatia
Dalibor Šimunović ; »J. J. Strossmayer« University, University Hospital Centre Osijek, Clinic of Urology, Osijek, Croatia
Josip Galić ; »J. J. Strossmayer« University, University Hospital Centre Osijek, Clinic of Urology, Osijek, Croatia


Puni tekst: engleski pdf 100 Kb

str. 907-911

preuzimanja: 385

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Sažetak

Recent studies suggest that chronic inflammation is crucial in the development and progression of prostate cancer (CaP). Interleukin-6 (IL-6) is a proinflammatory cytokine that plays an important role in intraprostatic inflammation and thus carcinogenesis. The –174G>C polymorphism of IL-6 gene has been associated with high IL-6 producer pheno- type and an increased risk for CaP . The aim of this study was to evaluate the association between the mentioned IL-6 polymorphism and CaP risk, as well as to compare the genotype frequency between the different tumour grades of CaP , in population of Eastern Croatia. We analyzed the IL-6 polymorphism in 120 CaP patients and 120 controls with benign prostatic hyperplasia (BPH). CaP patients and BPH controls did not statistically differ in studied IL-6 polymorphism. Furthermore, high IL-6 producer genotypes (GG or GC) were more frequent in controls than in CaP group (86.7% vs 80.8%, respectively, p=0.147). Also, no statistically significant difference in IL-6 high and low producer genotype fre- quency was noticed between well, moderately and poorly differentiated tumours. Our results, taken together with other studies on the subject, suggest that IL-6 – 174 single nucleotide polymorphism (SNP) distribution may differ between various ethnic groups and that a single cytokine gene polymorphism has probably just a minor effect on CaP susceptibil- ity. Further studies should be performed to clarify the link between SNPs of different cytokines and the risk for CaP .

Ključne riječi

prostate cancer; IL-6; SNPs; Croatia

Hrčak ID:

118292

URI

https://hrcak.srce.hr/118292

Datum izdavanja:

30.9.2013.

Posjeta: 1.504 *