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Interleukin-6 Polymorphism and Prostate Cancer Risk in Population of Eastern Croatia

Sanja Mandić ; »J. J. Strossmayer« University, University Hospital Centre Osijek, Department of Clinical Laboratory Diagnostics, Osijek, Croatia
Bojan Sudarević ; »J. J. Strossmayer« University, University Hospital Centre Osijek, Clinic of Urology, Osijek, Croatia
Saška Marczi ; »J. J. Strossmayer« University, University Hospital Centre Osijek, Clinical Institute of Nuclear Medicine and Radiation Protection, Department of Molecular Diagnostics and Tissue Typing, Osijek, Croatia
Vesna Horvat ; »J. J. Strossmayer« University, University Hospital Centre Osijek, Department of Clinical Laboratory Diagnostics, Osijek, Croatia
Ivan Ćosić ; »J. J. Strossmayer« University, University Hospital Centre Osijek, Clinic of Urology, Osijek, Croatia
Slobodan Mihaljević ; University of Zagreb, University Hospital Centre Zagreb, Clinic of Gynecology and Obstetrics, Department for Anaesthesiology, Zagreb, Croatia
Nevenka Miličević ; »J. J. Strossmayer« University, University Hospital Centre Osijek, Department of Anesthesiology, Reanimatology and Intensive Care Unit, Osijek, Croatia
Dalibor Šimunović ; »J. J. Strossmayer« University, University Hospital Centre Osijek, Clinic of Urology, Osijek, Croatia
Josip Galić ; »J. J. Strossmayer« University, University Hospital Centre Osijek, Clinic of Urology, Osijek, Croatia

Puni tekst: engleski, pdf (100 KB) str. 907-911 preuzimanja: 179* citiraj
APA 6th Edition
Mandić, S., Sudarević, B., Marczi, S., Horvat, V., Ćosić, I., Mihaljević, S., ... Galić, J. (2013). Interleukin-6 Polymorphism and Prostate Cancer Risk in Population of Eastern Croatia. Collegium antropologicum, 37 (3), 907-911. Preuzeto s https://hrcak.srce.hr/118292
MLA 8th Edition
Mandić, Sanja, et al. "Interleukin-6 Polymorphism and Prostate Cancer Risk in Population of Eastern Croatia." Collegium antropologicum, vol. 37, br. 3, 2013, str. 907-911. https://hrcak.srce.hr/118292. Citirano 18.09.2020.
Chicago 17th Edition
Mandić, Sanja, Bojan Sudarević, Saška Marczi, Vesna Horvat, Ivan Ćosić, Slobodan Mihaljević, Nevenka Miličević, Dalibor Šimunović i Josip Galić. "Interleukin-6 Polymorphism and Prostate Cancer Risk in Population of Eastern Croatia." Collegium antropologicum 37, br. 3 (2013): 907-911. https://hrcak.srce.hr/118292
Harvard
Mandić, S., et al. (2013). 'Interleukin-6 Polymorphism and Prostate Cancer Risk in Population of Eastern Croatia', Collegium antropologicum, 37(3), str. 907-911. Preuzeto s: https://hrcak.srce.hr/118292 (Datum pristupa: 18.09.2020.)
Vancouver
Mandić S, Sudarević B, Marczi S, Horvat V, Ćosić I, Mihaljević S i sur. Interleukin-6 Polymorphism and Prostate Cancer Risk in Population of Eastern Croatia. Collegium antropologicum [Internet]. 2013 [pristupljeno 18.09.2020.];37(3):907-911. Dostupno na: https://hrcak.srce.hr/118292
IEEE
S. Mandić, et al., "Interleukin-6 Polymorphism and Prostate Cancer Risk in Population of Eastern Croatia", Collegium antropologicum, vol.37, br. 3, str. 907-911, 2013. [Online]. Dostupno na: https://hrcak.srce.hr/118292. [Citirano: 18.09.2020.]

Sažetak
Recent studies suggest that chronic inflammation is crucial in the development and progression of prostate cancer (CaP). Interleukin-6 (IL-6) is a proinflammatory cytokine that plays an important role in intraprostatic inflammation and thus carcinogenesis. The –174G>C polymorphism of IL-6 gene has been associated with high IL-6 producer pheno- type and an increased risk for CaP . The aim of this study was to evaluate the association between the mentioned IL-6 polymorphism and CaP risk, as well as to compare the genotype frequency between the different tumour grades of CaP , in population of Eastern Croatia. We analyzed the IL-6 polymorphism in 120 CaP patients and 120 controls with benign prostatic hyperplasia (BPH). CaP patients and BPH controls did not statistically differ in studied IL-6 polymorphism. Furthermore, high IL-6 producer genotypes (GG or GC) were more frequent in controls than in CaP group (86.7% vs 80.8%, respectively, p=0.147). Also, no statistically significant difference in IL-6 high and low producer genotype fre- quency was noticed between well, moderately and poorly differentiated tumours. Our results, taken together with other studies on the subject, suggest that IL-6 – 174 single nucleotide polymorphism (SNP) distribution may differ between various ethnic groups and that a single cytokine gene polymorphism has probably just a minor effect on CaP susceptibil- ity. Further studies should be performed to clarify the link between SNPs of different cytokines and the risk for CaP .

Ključne riječi
prostate cancer; IL-6; SNPs; Croatia

Hrčak ID: 118292

URI
https://hrcak.srce.hr/118292

Posjeta: 826 *