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Impact of Prostaglandin F2-Alpha and Tumor Necrosis Factor-Alpha (TNF-a) on Pain in Patients Undergoing Thermal Balloon Endometrial Ablation

Bojan Grulović ; General Hospital Bre`ice, Department of Obstetrics and Gynaecology, Bre`ice, Slovenia
Martina Ribič Pucelj ; University of Ljubljana, University Medical Centre Ljubljana, Clinical Department of Obstetrics and Gynaecology, Ljubljana, Slovenia
Mladen Krnić ; University of Split, University Hospital Centre Split, University Department for Endocrinology, Diabetes and Metabolic Disease, Split, Croatia
Višnja Kokić ; University of Split, University Hospital Centre Split, University Department for Endocrinology, Diabetes and Metabolic Disease, Split, Croatia


Puni tekst: engleski pdf 107 Kb

str. 1185-1190

preuzimanja: 276

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Sažetak

The primary objective of the study was to evaluate the correlation between prostaglandin F2-alpha and tumour necro- sis factor-alpha concentration and that of pain experienced by patients undergoing thermal balloon ablation. Further- more we evaluated the correlation between the endometrial and myometrial thicknesses and the degree of pain experi- enced by patients undergoing the procedure, and in addition the correlation between PGF2-alpha, TNF-alpha and endo- metrial and myometrial thicknesses. Single-arm cohort study (Canadian Task force classification II-2). In University Medical Centre Ljubljana, outpatient setting, 40 perimenopausal women with dysfunctional uterine bleeding (DUB), un- derwent endometrial thermal balloon ablation. The thickness of the endometrium and myometrium was measured prior to surgery using a transvaginal ultrasound that provided cross-sectional images. The degree of pain was rated using the visual analogue scale (VAS) and numeric rating scale (NRS) immediately and 60 minutes after the procedure. The con- centration of PGF2-alpha and TNF-alpha in venous blood was measured prior to, at the end of and 60 minutes after the procedure. The results showed a positive correlation between the concentration of PGF2-alpha released during endo- metrial ablation and the endometrial and myometrial thickness (p>0.01), including the reported degree of pain (p> 0.01). The concentration of TNF-alpha indicates a positive correlation with the level of pain (p>0.05), but is not depend- ent on the thicknesses of the endometrium and myometrium. Endometrial thickness correlates to the degree of pain and the prostaglandin F2-alpha concentration. In clinical practice, performing the Gynecare ThermaChoice procedure im- mediately after menstruation or preoperative preparation of the endometrium using oral contraceptives enables this pro- cedure to be performed in outpatient settings and can be considered a valuable treatment option for DUB.

Ključne riječi

thermal balloon endometrial ablation (THERMACHOICE); pain; prostaglandins; tumor necrosis factor

Hrčak ID:

118366

URI

https://hrcak.srce.hr/118366

Datum izdavanja:

30.12.2013.

Posjeta: 658 *