Izvorni znanstveni članak
Expression of the BMP -2, -4 and -7 and their Antagonists Gremlin, Chordin, Noggin and Follistatin during Ectopic Osteogenesis
Luka Đudarić
; University of Rijeka, School of Medicine, Department of Anatomy, Rijeka, Croatia
Sanja Zoričić Cvek
; University of Rijeka, School of Medicine, Department of Anatomy, Rijeka, Croatia
Olga Cvijanović
; University of Rijeka, School of Medicine, Department of Anatomy, Rijeka, Croatia
Veljko Šantić
; Clinic for Orthopedic Surgery, Lovran, Croatia
Ivana Marić
; University of Rijeka, School of Medicine, Department of Anatomy, Rijeka, Croatia
Željka Crčević-Orlić
; University of Rijeka, University Hospital Center Rijeka, Department of Internal Medicine, Rijeka, Croatia
Dragica Bobinac
; University of Rijeka, School of Medicine, Department of Anatomy, Rijeka, Croatia
Sažetak
Molecular network of the osteogenic BMPs and extracellular inhibitors maintains homeostasis of the skeletal tissues. It is important to determine relationship between BMP-2, -4 and -7 and their inhibitors: gremlin, follistatin, chordin and noggin, during normal osteogenesis. To determine their expression pattern we conducted investigation by inducing ecto- pic bone formation in rats. The results shown that levels of the BMP-2 and BMP-4 expression in chondrocytes are similar to noggin and follistatin. The latter BMPs and inhibitors have increased levels of the expression at day 14 th of the osteo- genesis, which suggests their important roles in early phases of the chondrogenesis. Gremlin and chordin have shown increased levels of expression in late phase of chondrogenesis, which suggests their important role in regulation of the osteogenesis initiation. In this study, BMPs and inhibitors have the highest levels of the expression at 21 st day in the osteocytes, which suggests their strong interactions in osteogenesis.
Ključne riječi
ectopic osteogenesis; BMP-2; BMP-4; BMP-7; gremlin; chordin; noggin; follistatin
Hrčak ID:
118385
URI
Datum izdavanja:
30.12.2013.
Posjeta: 1.054 *