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Systemic Character of Legionnaires’ Disease – A Murine Model

Marina Šantić ; Department of Microbiology and Parasitology, Medical Faculty, University of Rijeka, Braće Branchetta 20, HR-51000 Rijeka, Croatia
Michael Bozic ; Molecular Diagnostics Laboratory, Institute of Hygiene, KF-University Graz, Universitaetplatz 4, A-8010 Graz, Austria
Harald H. Kessler ; Molecular Diagnostics Laboratory, Institute of Hygiene, KF-University Graz, Universitaetplatz 4, A-8010 Graz, Austria
Miljenko Dorić ; Department of Microbiology and Parasitology, Medical Faculty, University of Rijeka, Braće Branchetta 20, HR-51000 Rijeka, Croatia

Puni tekst: engleski, pdf (114 KB) str. 227-230 preuzimanja: 201* citiraj
APA 6th Edition
Šantić, M., Bozic, M., Kessler, H.H. i Dorić, M. (2003). Systemic Character of Legionnaires’ Disease – A Murine Model. Food Technology and Biotechnology, 41 (3), 227-230. Preuzeto s https://hrcak.srce.hr/118620
MLA 8th Edition
Šantić, Marina, et al. "Systemic Character of Legionnaires’ Disease – A Murine Model." Food Technology and Biotechnology, vol. 41, br. 3, 2003, str. 227-230. https://hrcak.srce.hr/118620. Citirano 20.10.2021.
Chicago 17th Edition
Šantić, Marina, Michael Bozic, Harald H. Kessler i Miljenko Dorić. "Systemic Character of Legionnaires’ Disease – A Murine Model." Food Technology and Biotechnology 41, br. 3 (2003): 227-230. https://hrcak.srce.hr/118620
Harvard
Šantić, M., et al. (2003). 'Systemic Character of Legionnaires’ Disease – A Murine Model', Food Technology and Biotechnology, 41(3), str. 227-230. Preuzeto s: https://hrcak.srce.hr/118620 (Datum pristupa: 20.10.2021.)
Vancouver
Šantić M, Bozic M, Kessler HH, Dorić M. Systemic Character of Legionnaires’ Disease – A Murine Model. Food Technology and Biotechnology [Internet]. 2003 [pristupljeno 20.10.2021.];41(3):227-230. Dostupno na: https://hrcak.srce.hr/118620
IEEE
M. Šantić, M. Bozic, H.H. Kessler i M. Dorić, "Systemic Character of Legionnaires’ Disease – A Murine Model", Food Technology and Biotechnology, vol.41, br. 3, str. 227-230, 2003. [Online]. Dostupno na: https://hrcak.srce.hr/118620. [Citirano: 20.10.2021.]

Sažetak
In contrast to lung infection caused by Legionella pneumophila, little is known about the pathogenesis of this disease in other organs. In this study, we analyzed the number of colony forming units (CFU) of legionellae not only in lungs but also in EDTA plasma, liver, spleen and kidneys. The number of CFU was determined 2, 24, 48, 72 and 168 h after intratracheal inoculation. Results showed that the inflammatory response was mostly pronounced in lungs. Legionellae, however, were also found in EDTA plasma and all the other investigated organs. The duration of infection was most protracted in lungs, with persistence for at least 168 h. In the remaining organs, legionellae were found for a maximum of 72 h after inoculation. Besides the culture methods used for detection of CFU we also
used LightCycler (LC) PCR to confirm the presence of bacteria in the blood of intratracheally infected mice. By this method the bacterial DNA could be detected during the first two days of post infection.

Ključne riječi
Legionnaires’ disease; systemic disease; animal model; real-time polymerase chain reaction

Hrčak ID: 118620

URI
https://hrcak.srce.hr/118620

Posjeta: 364 *