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Comparison Between Clinical Significance of Serum Proinflammatory Protein Interleukin-6 and Classic Tumor Markers Total PSA, Free PSA and Free/Total PSA Prior to Prostate Biopsy

Nevenka Miličević ; 1 »J. J. Strossmayer« University, University Hospital Centre Osijek, Reanimatology and Intensive Care Unit, Department of Anesthesiology, Osijek, Croatia
Milanka Mrčela ; »J. J. Strossmayer« University, University Hospital Centre Osijek, Department of Pathology and Forensic Medicine, Osijek, Croatia
Ivana Lukić ; »J. J. Strossmayer« University, School of Medicine, Osijek, Croatia
Sanja Mandić ; »J. J. Strossmayer« University, University Hospital Centre Osijek, Department of Clinical Laboratory Diagnostics, Osijek, Croatia
Vesna Horvat ; »J. J. Strossmayer« University, University Hospital Centre Osijek, Department of Clinical Laboratory Diagnostics, Osijek, Croatia
Josip Galić ; »J. J. Strossmayer« University, University Hospital Centre Osijek, Clinic of Urology, Osijek, Croatia

Puni tekst: engleski, pdf (82 KB) str. 147-150 preuzimanja: 255* citiraj
APA 6th Edition
Miličević, N., Mrčela, M., Lukić, I., Mandić, S., Horvat, V. i Galić, J. (2014). Comparison Between Clinical Significance of Serum Proinflammatory Protein Interleukin-6 and Classic Tumor Markers Total PSA, Free PSA and Free/Total PSA Prior to Prostate Biopsy. Collegium antropologicum, 38 (1), 147-150. Preuzeto s https://hrcak.srce.hr/120866
MLA 8th Edition
Miličević, Nevenka, et al. "Comparison Between Clinical Significance of Serum Proinflammatory Protein Interleukin-6 and Classic Tumor Markers Total PSA, Free PSA and Free/Total PSA Prior to Prostate Biopsy." Collegium antropologicum, vol. 38, br. 1, 2014, str. 147-150. https://hrcak.srce.hr/120866. Citirano 15.07.2020.
Chicago 17th Edition
Miličević, Nevenka, Milanka Mrčela, Ivana Lukić, Sanja Mandić, Vesna Horvat i Josip Galić. "Comparison Between Clinical Significance of Serum Proinflammatory Protein Interleukin-6 and Classic Tumor Markers Total PSA, Free PSA and Free/Total PSA Prior to Prostate Biopsy." Collegium antropologicum 38, br. 1 (2014): 147-150. https://hrcak.srce.hr/120866
Harvard
Miličević, N., et al. (2014). 'Comparison Between Clinical Significance of Serum Proinflammatory Protein Interleukin-6 and Classic Tumor Markers Total PSA, Free PSA and Free/Total PSA Prior to Prostate Biopsy', Collegium antropologicum, 38(1), str. 147-150. Preuzeto s: https://hrcak.srce.hr/120866 (Datum pristupa: 15.07.2020.)
Vancouver
Miličević N, Mrčela M, Lukić I, Mandić S, Horvat V, Galić J. Comparison Between Clinical Significance of Serum Proinflammatory Protein Interleukin-6 and Classic Tumor Markers Total PSA, Free PSA and Free/Total PSA Prior to Prostate Biopsy. Collegium antropologicum [Internet]. 2014 [pristupljeno 15.07.2020.];38(1):147-150. Dostupno na: https://hrcak.srce.hr/120866
IEEE
N. Miličević, M. Mrčela, I. Lukić, S. Mandić, V. Horvat i J. Galić, "Comparison Between Clinical Significance of Serum Proinflammatory Protein Interleukin-6 and Classic Tumor Markers Total PSA, Free PSA and Free/Total PSA Prior to Prostate Biopsy", Collegium antropologicum, vol.38, br. 1, str. 147-150, 2014. [Online]. Dostupno na: https://hrcak.srce.hr/120866. [Citirano: 15.07.2020.]

Sažetak
The aim of the study was to clarify whether serum levels of proinflammatory cytokine interleukin-6 (IL-6) could be a useful marker in prostate diseases. Serum IL-6 was determined prior to prostate biopsy procedure in 82 patients with prostate adenocarcinoma (PCa), 25 patients with benign prostatic hyperplasia (BPH), 24 patients with high-grade prostatic intraepithelial neoplasia (PIN) and 17 patients with chronic prostatitis. Serum IL-6 levels were compared with total PSA (tPSA), free PSA (fPSA) and the free/total ratio (f/tPSA) serum levels. Statistically significant difference was not found in serum IL-6 levels among the four groups (p=0.088). However, the patients with poorly differentiated PCa with Gleason score (GS) 4+3=7 and >7 had significantly higher serum IL-6 levels than the patients with moderately differentiated PCa with GS 3+4=7 and <7 (p=0.007). The findings suggest that serum IL-6 level might be a potentially useful marker for poorly differentiated PCa.

Ključne riječi
interleukin-6; serum levels; prostate biopsy; prostate-specific antigen; Gleason score

Hrčak ID: 120866

URI
https://hrcak.srce.hr/120866

Posjeta: 403 *