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Acta Pharmaceutica, Vol. 64 No. 3, 2014.

Izvorni znanstveni članak
https://doi.org/10.2478/acph-2014-0028

Novel ethyl 1,5-disubstituted-1H-pyrazole-3-carboxylates as a new class of antimicrobial agents

AWWAD A. RADWAN ; Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut-71527, Egypt
MOSTAFA M. GHORAB ; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, P.O. 2457, Riyadh 11451, Saudi Arabia; Department of Drug Radiation Research, National Centre For Radiation Research and Technology, Atomic Energy Authority, P.O. Box 29, Nasr
MANSOUR S. ALSAID ; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, P.O. 2457, Riyadh 11451, Saudi Arabia
FARES K. ALANAZI ; Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia

Puni tekst: engleski, pdf (279 KB) str. 335-344 preuzimanja: 537* citiraj
APA 6th Edition
RADWAN, A.A., GHORAB, M.M., ALSAID, M.S. i ALANAZI, F.K. (2014). Novel ethyl 1,5-disubstituted-1H-pyrazole-3-carboxylates as a new class of antimicrobial agents. Acta Pharmaceutica, 64 (3), 335-344. https://doi.org/10.2478/acph-2014-0028
MLA 8th Edition
RADWAN, AWWAD A., et al. "Novel ethyl 1,5-disubstituted-1H-pyrazole-3-carboxylates as a new class of antimicrobial agents." Acta Pharmaceutica, vol. 64, br. 3, 2014, str. 335-344. https://doi.org/10.2478/acph-2014-0028. Citirano 21.05.2019.
Chicago 17th Edition
RADWAN, AWWAD A., MOSTAFA M. GHORAB, MANSOUR S. ALSAID i FARES K. ALANAZI. "Novel ethyl 1,5-disubstituted-1H-pyrazole-3-carboxylates as a new class of antimicrobial agents." Acta Pharmaceutica 64, br. 3 (2014): 335-344. https://doi.org/10.2478/acph-2014-0028
Harvard
RADWAN, A.A., et al. (2014). 'Novel ethyl 1,5-disubstituted-1H-pyrazole-3-carboxylates as a new class of antimicrobial agents', Acta Pharmaceutica, 64(3), str. 335-344. doi: https://doi.org/10.2478/acph-2014-0028
Vancouver
RADWAN AA, GHORAB MM, ALSAID MS, ALANAZI FK. Novel ethyl 1,5-disubstituted-1H-pyrazole-3-carboxylates as a new class of antimicrobial agents. Acta Pharm. [Internet]. 2014 [pristupljeno 21.05.2019.];64(3):335-344. doi: https://doi.org/10.2478/acph-2014-0028
IEEE
A.A. RADWAN, M.M. GHORAB, M.S. ALSAID i F.K. ALANAZI, "Novel ethyl 1,5-disubstituted-1H-pyrazole-3-carboxylates as a new class of antimicrobial agents", Acta Pharmaceutica, vol.64, br. 3, str. 335-344, 2014. [Online]. doi: https://doi.org/10.2478/acph-2014-0028

Sažetak
A series of pyrazole derivatives 9-22 were designed and synthesized. All the newly synthesized compounds were assayed for their antimicrobial activity against the Gram-positive bacteria Staphyllococcus aureus and Bacillius subtilis and the Gram-negative bacteria Escherichia coli, Pseudomonas aeruginosa, in addition to the fungi organisms, Candida albicans, C. parapsilosis and C. tropicalis. Ethyl 5-(2,5-dimethylthiophen-3-yl)-1-phenyl-1H-pyrazole-3-carboxylate (21) (MICE.coli =0.038 µmol mL–1, MICP. aerug = 0.067 µmol mL–1) is nearly as active as ampicillin (MIC = 0.033 and 0.067 µmol mL–1, respectively). Ethyl 5-(4-bromo-2-chlorophenyl)-1-phenyl-1H-pyrazole-3-carboxylate (16) (MIC = 0.015 µmol mL–1) is more active than fluconazole (0.020 µmol mL–1) as a reference drug against C. parapsilosis.

Ključne riječi
pyrazole-3-carboxylates; antimicrobial screening

Hrčak ID: 121072

URI
https://hrcak.srce.hr/121072

Posjeta: 639 *