Stručni rad
A Retrospective Study of 231 Japanese Vitiligo Patients with Special Reference to Phototherapy
Akiko Yoshida
; Juntendo University
Atsushi Takagi
; Juntendo University
Ayako Ikejima
Hiroshi Takenaka
Tatsuo Fukai
Shigaku Ikeda
Sažetak
Although the outcomes of various treatment modalities for vitiligo have long been studied, the influence of each participant’s feature on treatment response has not been thoroughly investigated. Therefore, we aimed to retrospectively investigate treatment effect and its association with clinical characteristics in Japanese patients with vitiligo. The charts of vitiligo patients treated in our institution were reviewed. Clinical response was evaluated by marked response rate (repigmentation in >75% of the initial lesional area). 162 patients were treated with phototherapy while 69 were treated with topical mono-therapy. The overall patients treated with phototherapy or those who treated with both phototherapy and topical treatment demonstrated significantly higher clinical response rate compared to patients treated with topical mono-therapy (marked response rate: 19.1% vs. 5.8%, P<0.05; and 23.5% vs. 5.8%, P<0.01, respectively). Among the phototherapy-treated patients, younger subjects (£15 years old) were more responsive to phototherapy compared to older patients (37.0% vs. 15.6%; P=0.015). The disease subtypes did not affect treatment response. In conclusion, phototherapy appears to have a therapeutic effect superior to topical mono-therapy on both focal and generalized vitiligo, especially in younger patients. Thus, any type of psychosocially devastating lesions in a pediatric patient may be a good target for phototherapy.
Ključne riječi
excimer laser; focal vitiligo; generalized vitiligo; narrowband UVB; pediatric
Hrčak ID:
121303
URI
Datum izdavanja:
15.5.2014.
Posjeta: 1.104 *