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Izvorni znanstveni članak
Cytokeratin 18 & 19 Expression in Normal Mucosa, Lichen Planus and Squamous Cell Carcinoma
Dhanuthai Kittipong
Chaiyarit Ponlatham
Chowsrikul Wichian
Wongsana Parichart
Rojanawatsirivej Somsri
| Puni tekst: engleski, pdf (490 KB) | str. 23-30 | citiraj | |
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APA 6th Edition Kittipong, D., Ponlatham, C., Wichian, C., Parichart, W. i Somsri, R. (2007). Cytokeratin 18 & 19 Expression in Normal Mucosa, Lichen Planus and Squamous Cell Carcinoma. Acta stomatologica Croatica, 41 (1), 23-30. Preuzeto s https://hrcak.srce.hr/11687 MLA 8th Edition Kittipong, Dhanuthai, et al. "Cytokeratin 18 & 19 Expression in Normal Mucosa, Lichen Planus and Squamous Cell Carcinoma." Acta stomatologica Croatica, vol. 41, br. 1, 2007, str. 23-30. https://hrcak.srce.hr/11687. Citirano 26.02.2021. Chicago 17th Edition Kittipong, Dhanuthai, Chaiyarit Ponlatham, Chowsrikul Wichian, Wongsana Parichart i Rojanawatsirivej Somsri. "Cytokeratin 18 & 19 Expression in Normal Mucosa, Lichen Planus and Squamous Cell Carcinoma." Acta stomatologica Croatica 41, br. 1 (2007): 23-30. https://hrcak.srce.hr/11687 Harvard Kittipong, D., et al. (2007). 'Cytokeratin 18 & 19 Expression in Normal Mucosa, Lichen Planus and Squamous Cell Carcinoma', Acta stomatologica Croatica, 41(1), str. 23-30. Preuzeto s: https://hrcak.srce.hr/11687 (Datum pristupa: 26.02.2021.) Vancouver Kittipong D, Ponlatham C, Wichian C, Parichart W, Somsri R. Cytokeratin 18 & 19 Expression in Normal Mucosa, Lichen Planus and Squamous Cell Carcinoma. Acta stomatologica Croatica [Internet]. 2007 [pristupljeno 26.02.2021.];41(1):23-30. Dostupno na: https://hrcak.srce.hr/11687 IEEE D. Kittipong, C. Ponlatham, C. Wichian, W. Parichart i R. Somsri, "Cytokeratin 18 & 19 Expression in Normal Mucosa, Lichen Planus and Squamous Cell Carcinoma", Acta stomatologica Croatica, vol.41, br. 1, str. 23-30, 2007. [Online]. Dostupno na: https://hrcak.srce.hr/11687. [Citirano: 26.02.2021.] |
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| Puni tekst: hrvatski, pdf (490 KB) | str. 23-30 | citiraj | |
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APA 6th Edition Kittipong, D., Ponlatham, C., Wichian, C., Parichart, W. i Somsri, R. (2007). Ekspresija citokeratina 18 i 19 u normalnoj sluznici, lichen planusu i karcinomu pločastih stanica. Acta stomatologica Croatica, 41 (1), 23-30. Preuzeto s https://hrcak.srce.hr/11687 MLA 8th Edition Kittipong, Dhanuthai, et al. "Ekspresija citokeratina 18 i 19 u normalnoj sluznici, lichen planusu i karcinomu pločastih stanica." Acta stomatologica Croatica, vol. 41, br. 1, 2007, str. 23-30. https://hrcak.srce.hr/11687. Citirano 26.02.2021. Chicago 17th Edition Kittipong, Dhanuthai, Chaiyarit Ponlatham, Chowsrikul Wichian, Wongsana Parichart i Rojanawatsirivej Somsri. "Ekspresija citokeratina 18 i 19 u normalnoj sluznici, lichen planusu i karcinomu pločastih stanica." Acta stomatologica Croatica 41, br. 1 (2007): 23-30. https://hrcak.srce.hr/11687 Harvard Kittipong, D., et al. (2007). 'Ekspresija citokeratina 18 i 19 u normalnoj sluznici, lichen planusu i karcinomu pločastih stanica', Acta stomatologica Croatica, 41(1), str. 23-30. Preuzeto s: https://hrcak.srce.hr/11687 (Datum pristupa: 26.02.2021.) Vancouver Kittipong D, Ponlatham C, Wichian C, Parichart W, Somsri R. Ekspresija citokeratina 18 i 19 u normalnoj sluznici, lichen planusu i karcinomu pločastih stanica. Acta stomatologica Croatica [Internet]. 2007 [pristupljeno 26.02.2021.];41(1):23-30. Dostupno na: https://hrcak.srce.hr/11687 IEEE D. Kittipong, C. Ponlatham, C. Wichian, W. Parichart i R. Somsri, "Ekspresija citokeratina 18 i 19 u normalnoj sluznici, lichen planusu i karcinomu pločastih stanica", Acta stomatologica Croatica, vol.41, br. 1, str. 23-30, 2007. [Online]. Dostupno na: https://hrcak.srce.hr/11687. [Citirano: 26.02.2021.] |
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Sažetak
Cytokeratins (CK) are structural proteins in epithelial cells. Changes in cytokeratin expression have been observed during neoplastic transformation. Objectives: To evaluate cytokeratin 18 and 19 expression in normal mucosa, lichen planus and squamous cell carcinoma. Materials and methods: Thirty cases each of normal mucosa, lichen planus and squamous cell carcinoma were retrieved from the archives of the Department of Oral Diagnosis, Khon Kaen University. Tissue sections were stained with antibodies to cytokeratin 18 and 19. Immunoreactivity was evaluated by counting cells. The CK labeling indeks was calculated by dividing the number of positively stained cells x 100 by total number of cells counted. Results: 9 out of 30 (30.0%) normal mucosa, 5 out of 30 (16.7%) lichen planus and 4 out of 30 (13.3%) squamous cell carcinoma demonstrated positive staining for CK18. Squamous cell carcinoma showed the highest mean CK18 labeling index, followed in descending order by normal mucosa and lichen planus, respectively. Twenty three out of 30 (76.7%) normal mucosa, 9 out of 30 (30.0%) lichen planus and 1 out of 30 (3.33%) squamous cell carcinoma elicited positive staining for CK19. Normal mucosa elicited the highest mean CK19 labeling index, followed in descending order by lichen planus and squamous cell carcinoma, respectively. Conclusions: CK18 expression in normal mucosa, lichen planus and squamous cell carcinoma is low and there is no statistical difference among the three groups of lesions. CK 19 expression in normal mucosa is statistically higher than that of lichen planus and squamous cell carcinoma. CK19 might be a good candidate to be included in a panel of antibodies for detecting malignant transformation of oral mucosa into squamous cell carcinoma.
Ključne riječi
molecular biology; mouth mucosa; lichen planus; carcinoma; squamous cell
Hrčak ID: 11687
URI
https://hrcak.srce.hr/11687
Moj profil
Srce