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https://doi.org/10.2478/10004-1254-65-2014-2461

Photochemical toxicity of drugs intended for ocular use

Roshan Kumar Sahu ; CSIR-Open Source Drug Discovery Unit, Council of Scientific and Industrial Research Anusandhan Bhawan, New Delhi, India
Bhupendra Singh ; Department of Pharmaceutical Sciences, School for Biosciences & Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow, India
Shubhini A. Saraf ; Department of Pharmaceutical Sciences, School for Biosciences & Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow, India
Gaurav Kaithwas ; Department of Pharmaceutical Sciences, School for Biosciences & Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow, India
Kamal Kishor ; Indian Institute of Technology, Kanpur, India


Puni tekst: engleski pdf 522 Kb

str. 157-166

preuzimanja: 1.029

citiraj


Sažetak

The present investigation was undertaken to evaluate the possible ocular phototoxicity of drugs used in ophthalmic formulations. Sulphacetamide, ketoconazole, voriconazole, diclofenac, and ketorolac were assessed in the concentrations available in the market for their ocular use. The suitable models viz Hen’s Egg Test Chorioallantoic Membrane (HET-CAM) test, Isolated Chicken Eye (ICE) test, and Red Blood Cell (RBC) haemolysis test as recommended by ECVAM, ICCVAM, and OECD guidelines were performed. Results of HET-CAM and ICE tests suggest that sulphacetamide is moderately toxic in the presence of light/UV-A and very slightly irritant without irradiation. Ketoconazole and voriconazole were found slightly irritant in presence of light/UV-A and non-irritant in dark. Diclofenac and ketorolac demonstrated slight irritancy in the light and were found to be non-irritant in dark. The results suggest that some of the drugs have potential toxic effect in the presence of light. The extent of phototoxicity might get extended when used for longer time. The recommendation is that these drugs should be stored and used in the dark for a specified time and be labelled with specific instructions for patients, especially for those working longer in the sunlight.

Ključne riječi

antibacterial agents; antifungal agents; HET-CAM Test; ICE Test; NSAIDs; RBC Test

Hrčak ID:

122926

URI

https://hrcak.srce.hr/122926

Datum izdavanja:

11.6.2014.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.911 *