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Acta Pharmaceutica, Vol. 64 No. 4, 2014.

Izvorni znanstveni članak
https://doi.org/10.2478/acph-2014-0032

The influence of different formulations and process parameters during the preparation of drug-loaded PLGA microspheres evaluated by multivariate data analysis

JAKUB VYSLOUŽIL ; Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, 612 42 Brno, Czech Republic
PETR DOLEŽEL ; Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, 612 42 Brno, Czech Republic
MARTINA KEJDUŠOVÁ ; Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, 612 42 Brno, Czech Republic
ELIŠKA MAŠKOVÁ ; Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, 612 42 Brno, Czech Republic
JOSEF MAŠEK ; Department of Toxicology, Pharmacology and Immunotherapy, Veterinary Research Institute, 621 00 BRNO, Czech Republic
ROBERT LUKÁČ ; Department of Toxicology, Pharmacology and Immunotherapy, Veterinary Research Institute, 621 00 BRNO, Czech Republic
VRATISLAV KOŠŤÁL ; Tescan, 62300 Brno-Kohoutovice, Czech Republic
DAVID VETCHÝ ; Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, 612 42 Brno, Czech Republic
KATEŘINA DVOŘÁČKOVÁ ; Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, 612 42 Brno, Czech Republic

Puni tekst: engleski, pdf (954 KB) str. 403-417 preuzimanja: 1.568* citiraj
APA 6th Edition
VYSLOUŽIL, J., DOLEŽEL, P., KEJDUŠOVÁ, M., MAŠKOVÁ, E., MAŠEK, J., LUKÁČ, R., ... DVOŘÁČKOVÁ, K. (2014). The influence of different formulations and process parameters during the preparation of drug-loaded PLGA microspheres evaluated by multivariate data analysis. Acta Pharmaceutica, 64 (4), 403-417. https://doi.org/10.2478/acph-2014-0032
MLA 8th Edition
VYSLOUŽIL, JAKUB, et al. "The influence of different formulations and process parameters during the preparation of drug-loaded PLGA microspheres evaluated by multivariate data analysis." Acta Pharmaceutica, vol. 64, br. 4, 2014, str. 403-417. https://doi.org/10.2478/acph-2014-0032. Citirano 24.02.2019.
Chicago 17th Edition
VYSLOUŽIL, JAKUB, PETR DOLEŽEL, MARTINA KEJDUŠOVÁ, ELIŠKA MAŠKOVÁ, JOSEF MAŠEK, ROBERT LUKÁČ, VRATISLAV KOŠŤÁL, DAVID VETCHÝ i KATEŘINA DVOŘÁČKOVÁ. "The influence of different formulations and process parameters during the preparation of drug-loaded PLGA microspheres evaluated by multivariate data analysis." Acta Pharmaceutica 64, br. 4 (2014): 403-417. https://doi.org/10.2478/acph-2014-0032
Harvard
VYSLOUŽIL, J., et al. (2014). 'The influence of different formulations and process parameters during the preparation of drug-loaded PLGA microspheres evaluated by multivariate data analysis', Acta Pharmaceutica, 64(4), str. 403-417. doi: https://doi.org/10.2478/acph-2014-0032
Vancouver
VYSLOUŽIL J, DOLEŽEL P, KEJDUŠOVÁ M, MAŠKOVÁ E, MAŠEK J, LUKÁČ R i sur. The influence of different formulations and process parameters during the preparation of drug-loaded PLGA microspheres evaluated by multivariate data analysis. Acta Pharm. [Internet]. 2014 [pristupljeno 24.02.2019.];64(4):403-417. doi: https://doi.org/10.2478/acph-2014-0032
IEEE
J. VYSLOUŽIL, et al., "The influence of different formulations and process parameters during the preparation of drug-loaded PLGA microspheres evaluated by multivariate data analysis", Acta Pharmaceutica, vol.64, br. 4, str. 403-417, 2014. [Online]. doi: https://doi.org/10.2478/acph-2014-0032

Sažetak
The main objective of this study was to evaluate the influence of the formulation and process parameters on PLGA microparticles containing a practically insoluble model drug (ibuprofen) prepared by the o/w solvent evaporation method. Multivariate data analysis was used. The effects of altered stirring speed of a mechanical stirrer (600, 1000 rpm), emulsifier concentrations (PVA concentration 0.1 %, 1 %) and solvent selection (dichlormethane, ethyl acetate) on microparticles characteristics (encapsulation efficiency, drug loading, burst effect) were observed. It was found that with increased stirring speed, the PVA concentration or the use of ethyl acetate had a significantly negative effect on encapsulation efficiency. In addition, ethyl acetate had an adverse effect on the burst effect, while the increased stirring speed had the opposite effect. Drug load was not affected by any individual variable, but rather by the interactions of evaluated variables.

Ključne riječi
solvent evaporation; encapsulation; PLGA; controlled release; burst effect

Hrčak ID: 123219

URI
https://hrcak.srce.hr/123219

Posjeta: 1.710 *