David W. Brodell
; Washington University in St. Louis, St. Louis, MO, USA
Lawrence E. Frisch
; Northeastern Ohio Universities, College of Medicine, Rootstown, Ohio, USA
; Northeastern Ohio Universities, College of Medicine, Rootstown, Ohio, Case Western Reserve, School of Medicine, Cleveland, Ohio, University of Rochester, School of Medicine and Dentistry, Rochester, New York, USA
APA 6th Edition Brodell, D.W., Frisch, L.E. & Brodell, R. (2007). Debilitating Darier's disease. Signa vitae, 2 (1), 33-34. Retrieved from https://hrcak.srce.hr/11969
MLA 8th Edition Brodell, David W., et al. "Debilitating Darier's disease." Signa vitae, vol. 2, no. 1, 2007, pp. 33-34. https://hrcak.srce.hr/11969. Accessed 9 May 2021.
Chicago 17th Edition Brodell, David W., Lawrence E. Frisch and Robert Brodell. "Debilitating Darier's disease." Signa vitae 2, no. 1 (2007): 33-34. https://hrcak.srce.hr/11969
Harvard Brodell, D.W., Frisch, L.E., and Brodell, R. (2007). 'Debilitating Darier's disease', Signa vitae, 2(1), pp. 33-34. Available at: https://hrcak.srce.hr/11969 (Accessed 09 May 2021)
Vancouver Brodell DW, Frisch LE, Brodell R. Debilitating Darier's disease. Signa vitae [Internet]. 2007 [cited 2021 May 09];2(1):33-34. Available from: https://hrcak.srce.hr/11969
IEEE D.W. Brodell, L.E. Frisch and R. Brodell, "Debilitating Darier's disease", Signa vitae, vol.2, no. 1, pp. 33-34, 2007. [Online]. Available: https://hrcak.srce.hr/11969. [Accessed: 09 May 2021]
Abstracts Darier's disease is an inherited dermatitis that is due to a mutation in the ATP2A2 gene. This mutation causes disrupted signaling within cells and leads to a skin condition that is resistant to many dermatologic treatments. Though serious complications are rare, Darier's disease can result in bacterial sepsis and Kaposi's varicelliform eruption. In some families seizure disorders are linked to Darier's disease. There is also a paraneoplastic variant that could be considered in patients without a family history of Darier's disease. This article reports a case with typical verrucous masses and waxy papules which, over twenty years, became disabling. Symptoms included pruritus and foul odor and were relieved, along with the keratotic rash, utilizing systemic treatment with acitretin though the condition recurred rapidly when treatment was interrupted. Darier's disease must be considered when patients present with hyperkeratotic lesions that are resistant to usual forms of therapy for inflammatory dermatoses.