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Professional paper

Debilitating Darier's disease

David W. Brodell ; Washington University in St. Louis, St. Louis, MO, USA
Lawrence E. Frisch ; Northeastern Ohio Universities, College of Medicine, Rootstown, Ohio, USA
Robert Brodell ; Northeastern Ohio Universities, College of Medicine, Rootstown, Ohio, Case Western Reserve, School of Medicine, Cleveland, Ohio, University of Rochester, School of Medicine and Dentistry, Rochester, New York, USA

Fulltext: english, pdf (53 KB) pages 33-34 downloads: 613* cite
APA 6th Edition
Brodell, D.W., Frisch, L.E. & Brodell, R. (2007). Debilitating Darier's disease. Signa vitae, 2 (1), 33-34. Retrieved from
MLA 8th Edition
Brodell, David W., et al. "Debilitating Darier's disease." Signa vitae, vol. 2, no. 1, 2007, pp. 33-34. Accessed 24 Nov. 2020.
Chicago 17th Edition
Brodell, David W., Lawrence E. Frisch and Robert Brodell. "Debilitating Darier's disease." Signa vitae 2, no. 1 (2007): 33-34.
Brodell, D.W., Frisch, L.E., and Brodell, R. (2007). 'Debilitating Darier's disease', Signa vitae, 2(1), pp. 33-34. Available at: (Accessed 24 November 2020)
Brodell DW, Frisch LE, Brodell R. Debilitating Darier's disease. Signa vitae [Internet]. 2007 [cited 2020 November 24];2(1):33-34. Available from:
D.W. Brodell, L.E. Frisch and R. Brodell, "Debilitating Darier's disease", Signa vitae, vol.2, no. 1, pp. 33-34, 2007. [Online]. Available: [Accessed: 24 November 2020]

Darier's disease is an inherited dermatitis that is due to a mutation in the ATP2A2 gene. This mutation causes disrupted signaling within cells and leads to a skin condition that is resistant to many dermatologic treatments. Though serious complications are rare, Darier's disease can result in bacterial sepsis and Kaposi's varicelliform eruption. In some families seizure disorders are linked to Darier's disease. There is also a paraneoplastic variant that could be considered in patients without a family history of Darier's disease. This article reports a case with typical verrucous masses and waxy papules which, over twenty years, became disabling. Symptoms included pruritus and foul odor and were relieved, along with the keratotic rash, utilizing systemic treatment with acitretin though the condition recurred rapidly when treatment was interrupted. Darier's disease must be considered when patients present with hyperkeratotic lesions that are resistant to usual forms of therapy for inflammatory dermatoses.

Darier's Disease; ace-tretin; inherited dermatoses

Hrčak ID: 11969


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