Izvorni znanstveni članak

https://doi.org/10.11613/BM.2014.029

Oxidative status parameters in children with urinary tract infection

Stanislava Petrovic ; Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
Natasa Bogavac-Stanojevic ; Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
Jelena Kotur-Stevuljevic ; Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
Amira Peco-Antic ; School of Medicine, University of Belgrade, Belgrade, Serbia 3Department of Nephrology, University Children’s Hospital, Belgrade, Serbia
Ivana Ivanisevic ; School of Medicine, University of Belgrade, Belgrade, Serbia
Jasmina Ivanisevic ; Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
Dusan Paripovic ; Department of Nephrology, University Children’s Hospital, Belgrade, Serbia
Zorana Jelic-Ivanovic ; Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia

Sažetak

ntroduction: Urinary tract infection (UTI) is one of the most common bacterial infectious diseases in children. The aim of this study was to determine the total prooxidant and antioxidant capacity of children with UTI, as well as changes of oxidative status parameters according to acute inflammation persistence and acute kidney injury (AKI) development.
Materials and methods: The patients enrolled in the study comprised 50 Caucasian children (median age was 6 months) with UTI. Total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), inflammation marker C-reactive protein (CRP) and renal function parameters urea and creatinine were analyzed in patient’s serums.
Results: According to duration of inflammation during UTI, TAS values were significantly higher (0.99 vs. 0.58 mmol/L, P = 0.017) and OSI values were significantly lower (0.032 vs. 0.041 AU, P = 0.037) in the subjects with longer duration of inflammation than in the subjects with shorter duration of inflammation. We did not find significant difference in basal values of oxidative status parameters according to AKI development.
Conclusions: OSI values could detect the simultaneous change of TAS and TOS due to change in the oxidative-antioxidant balance during the recovery of children with UTI. TAS and OSI as markers of oxidative stress during UTI are sensitive to accompanying inflammatory condition. Further investigations are needed to evaluate whether TAS, TOS and OSI could be used to monitor disease severity in children with UTI.

Ključne riječi

oxidative stress; inflammation; acute kidney injury

Hrčak ID:

125432

URI

https://hrcak.srce.hr/125432

Datum izdavanja:

15.6.2014.

Posjeta: 1.301 *