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Acta Pharmaceutica, Vol. 57 No. 3, 2007.

Izvorni znanstveni članak
https://doi.org/10.2478/v10007-007-0025-5

Dizajn, razvoj i vrednovanje novih nanoemulzija za transdermalnu primjenu celekoksiba

SANJULA BABOOTA
FAIYAZ SHAKEEL
ALKA AHUJA
JAVED ALI
SHEIKH SHAFIQ

Puni tekst: engleski, pdf (377 KB) str. 315-332 preuzimanja: 6.742* citiraj
APA 6th Edition
BABOOTA, S., SHAKEEL, F., AHUJA, A., ALI, J. i SHAFIQ, S. (2007). Design, development and evaluation of novel nanoemulsion formulations for transdermal potential of celecoxib. Acta Pharmaceutica, 57 (3), 315-332. https://doi.org/10.2478/v10007-007-0025-5
MLA 8th Edition
BABOOTA, SANJULA, et al. "Design, development and evaluation of novel nanoemulsion formulations for transdermal potential of celecoxib." Acta Pharmaceutica, vol. 57, br. 3, 2007, str. 315-332. https://doi.org/10.2478/v10007-007-0025-5. Citirano 24.05.2019.
Chicago 17th Edition
BABOOTA, SANJULA, FAIYAZ SHAKEEL, ALKA AHUJA, JAVED ALI i SHEIKH SHAFIQ. "Design, development and evaluation of novel nanoemulsion formulations for transdermal potential of celecoxib." Acta Pharmaceutica 57, br. 3 (2007): 315-332. https://doi.org/10.2478/v10007-007-0025-5
Harvard
BABOOTA, S., et al. (2007). 'Design, development and evaluation of novel nanoemulsion formulations for transdermal potential of celecoxib', Acta Pharmaceutica, 57(3), str. 315-332. doi: https://doi.org/10.2478/v10007-007-0025-5
Vancouver
BABOOTA S, SHAKEEL F, AHUJA A, ALI J, SHAFIQ S. Design, development and evaluation of novel nanoemulsion formulations for transdermal potential of celecoxib. Acta Pharm. [Internet]. 2007 [pristupljeno 24.05.2019.];57(3):315-332. doi: https://doi.org/10.2478/v10007-007-0025-5
IEEE
S. BABOOTA, F. SHAKEEL, A. AHUJA, J. ALI i S. SHAFIQ, "Design, development and evaluation of novel nanoemulsion formulations for transdermal potential of celecoxib", Acta Pharmaceutica, vol.57, br. 3, str. 315-332, 2007. [Online]. doi: https://doi.org/10.2478/v10007-007-0025-5

Sažetak
U radu su opisana ispitivanja nanoemulzija za transdermalnu primjenu celekoksiba (CXB). Profil permeacije kroz kožu ispitivan je in vitro i uspoređivan sa CXB gelom i nanoemulzijskim gelom. U formulacijama T1 i T2 postignuto je značajno povećanje ustaljenog fluksa (Jss), koeficijenta permeabilnosti (Kp) i povećanje omjera (Er) (p < 0.05). Najveće vrijednosti parametara permeabilnosti dobivene su u formulaciji T2 koja je sadržala 2% m/m CXB, 10% m/m uljne faze (Sefsol 218 i Triacetin), 50% m/m površinski-aktivnih tvari (Tween-80 i Transcutol-P) i 40% m/m vode. Protuupalno djelovanje formulacije T2 na edem šape štakora uzrokovan karageninom značajno je povećano (p < 0.05) poslije 24 h u usporedbi sa CXB gelom i nanoemulzijskim gelom. Rezultati ukazuju na poboljšanu isporuku celekoksiba putem nanoemulzija.

Ključne riječi
celekoksib; nanoemulzije; mikroemulzije; nanoemulzijksi gel; transdermalna primjena; protuupalno djelovanje

Hrčak ID: 12061

URI
https://hrcak.srce.hr/12061

[engleski]

Posjeta: 7.513 *