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Acta Pharmaceutica, Vol. 57 No. 3, 2007.

Izvorni znanstveni članak
https://doi.org/10.2478/v10007-007-0025-5

Design, development and evaluation of novel nanoemulsion formulations for transdermal potential of celecoxib

SANJULA BABOOTA
FAIYAZ SHAKEEL
ALKA AHUJA
JAVED ALI
SHEIKH SHAFIQ

Puni tekst: engleski, pdf (377 KB) str. 315-332 preuzimanja: 6.630* citiraj
APA 6th Edition
BABOOTA, S., SHAKEEL, F., AHUJA, A., ALI, J. i SHAFIQ, S. (2007). Design, development and evaluation of novel nanoemulsion formulations for transdermal potential of celecoxib. Acta Pharmaceutica, 57 (3), 315-332. https://doi.org/10.2478/v10007-007-0025-5
MLA 8th Edition
BABOOTA, SANJULA, et al. "Design, development and evaluation of novel nanoemulsion formulations for transdermal potential of celecoxib." Acta Pharmaceutica, vol. 57, br. 3, 2007, str. 315-332. https://doi.org/10.2478/v10007-007-0025-5. Citirano 17.02.2019.
Chicago 17th Edition
BABOOTA, SANJULA, FAIYAZ SHAKEEL, ALKA AHUJA, JAVED ALI i SHEIKH SHAFIQ. "Design, development and evaluation of novel nanoemulsion formulations for transdermal potential of celecoxib." Acta Pharmaceutica 57, br. 3 (2007): 315-332. https://doi.org/10.2478/v10007-007-0025-5
Harvard
BABOOTA, S., et al. (2007). 'Design, development and evaluation of novel nanoemulsion formulations for transdermal potential of celecoxib', Acta Pharmaceutica, 57(3), str. 315-332. doi: https://doi.org/10.2478/v10007-007-0025-5
Vancouver
BABOOTA S, SHAKEEL F, AHUJA A, ALI J, SHAFIQ S. Design, development and evaluation of novel nanoemulsion formulations for transdermal potential of celecoxib. Acta Pharm. [Internet]. 2007 [pristupljeno 17.02.2019.];57(3):315-332. doi: https://doi.org/10.2478/v10007-007-0025-5
IEEE
S. BABOOTA, F. SHAKEEL, A. AHUJA, J. ALI i S. SHAFIQ, "Design, development and evaluation of novel nanoemulsion formulations for transdermal potential of celecoxib", Acta Pharmaceutica, vol.57, br. 3, str. 315-332, 2007. [Online]. doi: https://doi.org/10.2478/v10007-007-0025-5

Sažetak
The aim of the present study was to investigate the potential of nanoemulsion formulations for transdermal delivery of celecoxib (CXB). The in vitro skin permeation profile of optimized formulations was compared with CXB gel and nanoemulsion gel. Significant increase in the steady state flux (Jss), permeability coefficient (Kp) and enhancement ratio (Er) was observed in nanoemulsion formulations T1 and T2 (p < 0.05). The highest value of these permeability parameters was obtained in formulation T2, which consisted of 2% m/m of CXB, 10% m/m of oil phase (Sefsol 218 and Triacetin), 50% m/m of surfactant mixture (Tween-80 and Transcutol-P) and 40% m/m of water. The anti-inflammatory effects of formulation T2 showed a significant increase (p < 0.05) in inhibition after 24 h compared to CXB gel and nanoemulsion gel on carrageenean-induced paw edema in rats. These results suggested that nanoemulsions are potential vehicles for improved transdermal delivery of CXB.

Ključne riječi
celecoxib; nanoemulsions; microemulsions; nanoemulsion gels; transdermal delivery; anti-inflammatory effect

Hrčak ID: 12061

URI
https://hrcak.srce.hr/12061

[hrvatski]

Posjeta: 7.398 *