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Acta Pharmaceutica, Vol. 57 No. 3, 2007.

Kratko priopćenje
https://doi.org/10.2478/v10007-007-0029-1

Sinteza i antihipoksično djelovanje alifatskih i arilalifatskih amida kofein-8-tioglikolne kiseline

JAVOR MITKOV
JAVOR MITKOV
NIKOLAI DANCHEV
IRINA NIKOLOVA
ALEXANDER ZLATKOV

Puni tekst: engleski, pdf (83 KB) str. 361-370 preuzimanja: 605* citiraj
APA 6th Edition
MITKOV, J., MITKOV, J., DANCHEV, N., NIKOLOVA, I. i ZLATKOV, A. (2007). Synthesis and brain antihypoxic activity of some aliphatic and arylaliphatic amides of caffeine-8-thioglycolic acid. Acta Pharmaceutica, 57 (3), 361-370. https://doi.org/10.2478/v10007-007-0029-1
MLA 8th Edition
MITKOV, JAVOR, et al. "Synthesis and brain antihypoxic activity of some aliphatic and arylaliphatic amides of caffeine-8-thioglycolic acid." Acta Pharmaceutica, vol. 57, br. 3, 2007, str. 361-370. https://doi.org/10.2478/v10007-007-0029-1. Citirano 20.05.2019.
Chicago 17th Edition
MITKOV, JAVOR, JAVOR MITKOV, NIKOLAI DANCHEV, IRINA NIKOLOVA i ALEXANDER ZLATKOV. "Synthesis and brain antihypoxic activity of some aliphatic and arylaliphatic amides of caffeine-8-thioglycolic acid." Acta Pharmaceutica 57, br. 3 (2007): 361-370. https://doi.org/10.2478/v10007-007-0029-1
Harvard
MITKOV, J., et al. (2007). 'Synthesis and brain antihypoxic activity of some aliphatic and arylaliphatic amides of caffeine-8-thioglycolic acid', Acta Pharmaceutica, 57(3), str. 361-370. doi: https://doi.org/10.2478/v10007-007-0029-1
Vancouver
MITKOV J, MITKOV J, DANCHEV N, NIKOLOVA I, ZLATKOV A. Synthesis and brain antihypoxic activity of some aliphatic and arylaliphatic amides of caffeine-8-thioglycolic acid. Acta Pharm. [Internet]. 2007 [pristupljeno 20.05.2019.];57(3):361-370. doi: https://doi.org/10.2478/v10007-007-0029-1
IEEE
J. MITKOV, J. MITKOV, N. DANCHEV, I. NIKOLOVA i A. ZLATKOV, "Synthesis and brain antihypoxic activity of some aliphatic and arylaliphatic amides of caffeine-8-thioglycolic acid", Acta Pharmaceutica, vol.57, br. 3, str. 361-370, 2007. [Online]. doi: https://doi.org/10.2478/v10007-007-0029-1

Sažetak
U radu je opisana sinteza alifatskih i arilalifatskih amida kofein-8-tioglikolne kiseline i njihova karakterizacija elementarnom analizom, IR- i 1H NMR spektroskopijom. Testiranja na miševima pokazuju da su sintetizirani spojevi primijenjeni p.o. i i.p. manje toksični od kofeina. Smanjenje lokomotoričke aktivnosti podupire ideju o njihovom depresivnom djelovanju na SŽS. Spojevi 5a i 5b djeluju antihipoksički u uvjetima krvne i cirkulacijske hipoksije u mozgu.

Ključne riječi
kofein-8-tioglikolna kiselina; alifatski i arilalifatski amidi; antihipoksično djelovanje u mozgu; akutna toksičnost

Hrčak ID: 12064

URI
https://hrcak.srce.hr/12064

[engleski]

Posjeta: 1.023 *