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Acta Pharmaceutica, Vol. 57 No. 3, 2007.

Kratko priopćenje
https://doi.org/10.2478/v10007-007-0029-1

Synthesis and brain antihypoxic activity of some aliphatic and arylaliphatic amides of caffeine-8-thioglycolic acid

JAVOR MITKOV
JAVOR MITKOV
NIKOLAI DANCHEV
IRINA NIKOLOVA
ALEXANDER ZLATKOV

Puni tekst: engleski, pdf (83 KB) str. 361-370 preuzimanja: 585* citiraj
APA 6th Edition
MITKOV, J., MITKOV, J., DANCHEV, N., NIKOLOVA, I. i ZLATKOV, A. (2007). Synthesis and brain antihypoxic activity of some aliphatic and arylaliphatic amides of caffeine-8-thioglycolic acid. Acta Pharmaceutica, 57 (3), 361-370. https://doi.org/10.2478/v10007-007-0029-1
MLA 8th Edition
MITKOV, JAVOR, et al. "Synthesis and brain antihypoxic activity of some aliphatic and arylaliphatic amides of caffeine-8-thioglycolic acid." Acta Pharmaceutica, vol. 57, br. 3, 2007, str. 361-370. https://doi.org/10.2478/v10007-007-0029-1. Citirano 21.02.2019.
Chicago 17th Edition
MITKOV, JAVOR, JAVOR MITKOV, NIKOLAI DANCHEV, IRINA NIKOLOVA i ALEXANDER ZLATKOV. "Synthesis and brain antihypoxic activity of some aliphatic and arylaliphatic amides of caffeine-8-thioglycolic acid." Acta Pharmaceutica 57, br. 3 (2007): 361-370. https://doi.org/10.2478/v10007-007-0029-1
Harvard
MITKOV, J., et al. (2007). 'Synthesis and brain antihypoxic activity of some aliphatic and arylaliphatic amides of caffeine-8-thioglycolic acid', Acta Pharmaceutica, 57(3), str. 361-370. doi: https://doi.org/10.2478/v10007-007-0029-1
Vancouver
MITKOV J, MITKOV J, DANCHEV N, NIKOLOVA I, ZLATKOV A. Synthesis and brain antihypoxic activity of some aliphatic and arylaliphatic amides of caffeine-8-thioglycolic acid. Acta Pharm. [Internet]. 2007 [pristupljeno 21.02.2019.];57(3):361-370. doi: https://doi.org/10.2478/v10007-007-0029-1
IEEE
J. MITKOV, J. MITKOV, N. DANCHEV, I. NIKOLOVA i A. ZLATKOV, "Synthesis and brain antihypoxic activity of some aliphatic and arylaliphatic amides of caffeine-8-thioglycolic acid", Acta Pharmaceutica, vol.57, br. 3, str. 361-370, 2007. [Online]. doi: https://doi.org/10.2478/v10007-007-0029-1

Sažetak
The synthesis of some aliphatic and arylaliphatic amides of caffeine-8-thioglycolic acid was studied. The structures of synthesized compounds were proved by microanalyses, IR- and 1H NMR data. Values of acute p.o. and i.p. toxicity in mice show lower toxicity compared to caffeine. Declines in spontaneous locomotor activity support the idea of depressive CNS activity of the compounds. Two compounds exhibited brain antihypoxic activity (5a and 5b against haemic and circulatory hypoxia, respectively).

Ključne riječi
caffeine-8-thioglycolic acid; aliphatic and arylaliphatic amides; brain antihypoxic activity; acute toxicity

Hrčak ID: 12064

URI
https://hrcak.srce.hr/12064

[hrvatski]

Posjeta: 996 *