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Acta Pharmaceutica, Vol. 57 No. 3, 2007

Short communication, Note
https://doi.org/10.2478/v10007-007-0028-2

Priprava kompleksa etorikoksiba s β-ciklodekstrinom metodom gnječenja i njihova karakterizacija

HARESH M. PATEL
BHANUBHAI N. SUHAGIA
SHAILESH A. SHAH
ISHWAR SINH RATHOD
VIJAY K. PARMAR

Fulltext: english, pdf (157 KB) pages 351-359 downloads: 1.836* cite
APA 6th Edition
PATEL, H.M., SUHAGIA, B.N., SHAH, S.A., RATHOD, I.S. & PARMAR, V.K. (2007). Preparation and characterization of etoricoxib -cyclodextrin complexes prepared by the kneading method. Acta Pharmaceutica, 57 (3), 351-359. https://doi.org/10.2478/v10007-007-0028-2
MLA 8th Edition
PATEL, HARESH M., et al. "Preparation and characterization of etoricoxib -cyclodextrin complexes prepared by the kneading method." Acta Pharmaceutica, vol. 57, no. 3, 2007, pp. 351-359. https://doi.org/10.2478/v10007-007-0028-2. Accessed 25 Mar. 2019.
Chicago 17th Edition
PATEL, HARESH M., BHANUBHAI N. SUHAGIA, SHAILESH A. SHAH, ISHWAR SINH RATHOD and VIJAY K. PARMAR. "Preparation and characterization of etoricoxib -cyclodextrin complexes prepared by the kneading method." Acta Pharmaceutica 57, no. 3 (2007): 351-359. https://doi.org/10.2478/v10007-007-0028-2
Harvard
PATEL, H.M., et al. (2007). 'Preparation and characterization of etoricoxib -cyclodextrin complexes prepared by the kneading method', Acta Pharmaceutica, 57(3), pp. 351-359. doi: https://doi.org/10.2478/v10007-007-0028-2
Vancouver
PATEL HM, SUHAGIA BN, SHAH SA, RATHOD IS, PARMAR VK. Preparation and characterization of etoricoxib -cyclodextrin complexes prepared by the kneading method. Acta Pharm. [Internet]. 2007 [cited 2019 March 25];57(3):351-359. doi: https://doi.org/10.2478/v10007-007-0028-2
IEEE
H.M. PATEL, B.N. SUHAGIA, S.A. SHAH, I.S. RATHOD and V.K. PARMAR, "Preparation and characterization of etoricoxib -cyclodextrin complexes prepared by the kneading method", Acta Pharmaceutica, vol.57, no. 3, pp. 351-359, 2007. [Online]. doi: https://doi.org/10.2478/v10007-007-0028-2

Abstracts
Metodom gnječenja pripravljen je binarni sustav etorikoksiba s β-ciklodekstrinom (β-CD). Tijekom 30 minuta iz kompleksa se oslobodilo više od 75% ljekovite tvari, što je značajno više u odnosu na fizičku smjesu etorikoksiba i β-CD ili na čistu ljekovitu tvar. Interakcije lijeka i ciklodekstrina u otopini ispitivane su analizom fazne topljivosti. Za karakterizaciju čvrstog stanja svih binarnih sustava korišteni su diferencijalna pretražna kalorimetrija, infracrvena spektroskopija, difrakcija rentgenskih zraka na praškastom uzorku i mikroskopija. Oslobađanje je praćeno metodom lopatice prema USP XXIII. Rezultati ukazuju na djelomičnu interakciju ljekovite tvari s β-CD u fizičkoj smjesi i potpunu interakciju u kompleksu.

Keywords
etorikoksib; ciklodekstrin; kompleksacija; metoda gnječenja

Hrčak ID: 12065

URI
https://hrcak.srce.hr/12065

[english]

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