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Clinical features of the SAPHO syndrome and their role in choosing the therapeutic approach: report of four patients and review of the literature

Branimir Anić ; Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, University of Zagreb School of Medicine, University Hospital Centre Zagreb
Ivan Padjen ; Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, University of Zagreb School of Medicine, University Hospital Centre Zagreb
Miroslav Mayer ; Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, University of Zagreb School of Medicine, University Hospital Centre Zagreb
Dubravka Bosnić ; Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, University of Zagreb School of Medicine, University Hospital Centre Zagreb
Mislav Cerovec ; Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, University of Zagreb School of Medicine, University Hospital Centre Zagreb

Fulltext: english, PDF (189 KB) pages 180-180 downloads: 806* cite
APA 6th Edition
Anić, B., Padjen, I., Mayer, M., Bosnić, D. & Cerovec, M. (2014). Clinical features of the SAPHO syndrome and their role in choosing the therapeutic approach: report of four patients and review of the literature. Acta Dermatovenerologica Croatica, 22 (3), 180-180. Retrieved from https://hrcak.srce.hr/126591
MLA 8th Edition
Anić, Branimir, et al. "Clinical features of the SAPHO syndrome and their role in choosing the therapeutic approach: report of four patients and review of the literature." Acta Dermatovenerologica Croatica, vol. 22, no. 3, 2014, pp. 180-180. https://hrcak.srce.hr/126591. Accessed 30 Nov. 2021.
Chicago 17th Edition
Anić, Branimir, Ivan Padjen, Miroslav Mayer, Dubravka Bosnić and Mislav Cerovec. "Clinical features of the SAPHO syndrome and their role in choosing the therapeutic approach: report of four patients and review of the literature." Acta Dermatovenerologica Croatica 22, no. 3 (2014): 180-180. https://hrcak.srce.hr/126591
Harvard
Anić, B., et al. (2014). 'Clinical features of the SAPHO syndrome and their role in choosing the therapeutic approach: report of four patients and review of the literature', Acta Dermatovenerologica Croatica, 22(3), pp. 180-180. Available at: https://hrcak.srce.hr/126591 (Accessed 30 November 2021)
Vancouver
Anić B, Padjen I, Mayer M, Bosnić D, Cerovec M. Clinical features of the SAPHO syndrome and their role in choosing the therapeutic approach: report of four patients and review of the literature. Acta Dermatovenerol Croat. [Internet]. 2014 [cited 2021 November 30];22(3):180-180. Available from: https://hrcak.srce.hr/126591
IEEE
B. Anić, I. Padjen, M. Mayer, D. Bosnić and M. Cerovec, "Clinical features of the SAPHO syndrome and their role in choosing the therapeutic approach: report of four patients and review of the literature", Acta Dermatovenerologica Croatica, vol.22, no. 3, pp. 180-180, 2014. [Online]. Available: https://hrcak.srce.hr/126591. [Accessed: 30 November 2021]

Abstracts

Although the SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome was defined as a distinct entity more than 20 years ago, its classification within the spectrum of inflammatory rheumatic diseases and the proper therapeutic approach are still a matter of debate. We present four patients diagnosed with the SAPHO syndrome treated and followed-up in our Department, demonstrating the diversity of their clinical courses and their responses to different therapeutic approaches. We also review the clinical, laboratory, and imaging features of the SAPHO syndrome described in the relevant literature. Despite the growing quantity of published data on the clinical features of the syndrome and the recognition of two disease patterns (inflammatory and bone remodeling disease), it is still not clear whether these possible disease subsets require different therapeutic strategies. Tumor necrosis factor-alpha (TNF-α) inhibitors have been suggested to be effective in patients with the inflammatory pattern, whereas bisphosphonates seem to be effective in patients with bone remodeling disease; however, this is still a hypothesis not yet confirmed by adequately designed clinical studies. Further research is needed to assess disease features predicting favorable response to the two therapeutic modalities beyond the first line of therapy – TNF-α inhibitors and bisphosphonates.

Hrčak ID: 126591

URI
https://hrcak.srce.hr/126591

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