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Filaggrin Single Nucleotide Polymorphisms in Atopic Dermatitis

Mojdeh Khaledi
Akbar Fotouhi
Elham Farhadi
Behnaz Mahdaviani
Soheila Sotoudeh
Mehdi Tavakoli
Nasrin Behniafard
Mohammad Gharagozlou
Nima Rezaei

Puni tekst: engleski, PDF (137 KB) str. 200-200 preuzimanja: 498* citiraj
APA 6th Edition
Khaledi, M., Fotouhi, A., Farhadi, E., Mahdaviani, B., Sotoudeh, S., Tavakoli, M., ... Rezaei, N. (2014). Filaggrin Single Nucleotide Polymorphisms in Atopic Dermatitis. Acta Dermatovenerologica Croatica, 22 (3), 200-200. Preuzeto s https://hrcak.srce.hr/126594
MLA 8th Edition
Khaledi, Mojdeh, et al. "Filaggrin Single Nucleotide Polymorphisms in Atopic Dermatitis." Acta Dermatovenerologica Croatica, vol. 22, br. 3, 2014, str. 200-200. https://hrcak.srce.hr/126594. Citirano 22.10.2021.
Chicago 17th Edition
Khaledi, Mojdeh, Akbar Fotouhi, Elham Farhadi, Behnaz Mahdaviani, Soheila Sotoudeh, Mehdi Tavakoli, Nasrin Behniafard, Mohammad Gharagozlou i Nima Rezaei. "Filaggrin Single Nucleotide Polymorphisms in Atopic Dermatitis." Acta Dermatovenerologica Croatica 22, br. 3 (2014): 200-200. https://hrcak.srce.hr/126594
Harvard
Khaledi, M., et al. (2014). 'Filaggrin Single Nucleotide Polymorphisms in Atopic Dermatitis', Acta Dermatovenerologica Croatica, 22(3), str. 200-200. Preuzeto s: https://hrcak.srce.hr/126594 (Datum pristupa: 22.10.2021.)
Vancouver
Khaledi M, Fotouhi A, Farhadi E, Mahdaviani B, Sotoudeh S, Tavakoli M i sur. Filaggrin Single Nucleotide Polymorphisms in Atopic Dermatitis. Acta Dermatovenerol Croat. [Internet]. 2014 [pristupljeno 22.10.2021.];22(3):200-200. Dostupno na: https://hrcak.srce.hr/126594
IEEE
M. Khaledi, et al., "Filaggrin Single Nucleotide Polymorphisms in Atopic Dermatitis", Acta Dermatovenerologica Croatica, vol.22, br. 3, str. 200-200, 2014. [Online]. Dostupno na: https://hrcak.srce.hr/126594. [Citirano: 22.10.2021.]

Sažetak

Atopic Dermatitis (AD) is a relapsing chronic pruritic inflammatory disease of skin in which no monogenic cause has been identified so far. Meanwhile Filaggrin (FLG) gene is considered as the most important gene associated with predisposition to the disease.

One hundred and six patients with AD and 105 healthy individuals were enrolled in this study. Real time polymerase chain reaction was performed to determine frequencies of alleles and genotype in six variants of FLG gene.

Atopic dermatitis (AD) is a relapsing chronic pruritic inflammatory disease of skin for which no monogenic cause has been identified so far. Meanwhile, the filaggrin (FLG) gene is considered as the most important gene associated with predisposition to the disease.

One hundred and six patients with AD and 105 healthy individuals were enrolled in this study. Real time polymerase chain reaction was performed to determine frequencies of alleles and genotype in six variants of the FLG gene. The frequencies of allele A in variants of rs3126065, rs2786680, and rs1933063 as well as allele C in variant rs3814300 were 100%. There was no significant difference between allele frequencies in variants rs2485518 and rs3814299. The only genotypes in variants of rs3814299 and rs2485518 were GG and CC, respectively, with no significant difference between the patients and controls. This study demonstrated that there was no significant association between polymorphisms of FLG gene variants and AD.

Hrčak ID: 126594

URI
https://hrcak.srce.hr/126594

Posjeta: 1.042 *