Skoči na glavni sadržaj

Chemical and Biochemical Engineering Quarterly, Vol. 28 No. 3, 2014.

Izvorni znanstveni članak

https://doi.org/10.15255/CABEQ.2013.1835

Drug Nanocrystals: Theoretical Background of Solubility Increase and Dissolution Rate Enhancement

D. Hasa ; Department of Chemical and Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, I-34127, Trieste, Italy
B. Perissutti ; Department of Chemical and Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, I-34127, Trieste, Italy
D. Voinovich ; Department of Chemical and Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, I-34127, Trieste, Italy
M. Abrami ; Department of Engineering and Architercture, Via A. Valerio 6/A, I-34127, Trieste, Italy
R. Farra ; Department of Engineering and Architercture, Via A. Valerio 6/A, I-34127, Trieste, Italy
S. M. Fiorentino ; Department of Engineering and Architercture, Via A. Valerio 6/A, I-34127, Trieste, Italy
G. Grassi ; Department of Life Sciences, Cattinara University Hospital, Strada di Fiume 447, I-34149, Trieste, Italy
M. Grassi orcid id orcid.org/0000-0002-3532-3200 ; Department of Engineering and Architercture, Via A. Valerio 6/A, I-34127, Trieste, Italy

Puni tekst: engleski pdf 723 Kb

str. 247-258

preuzimanja: 747

citiraj

Sažetak

The peculiar higher solubility of drug nanocrystals compared to macrocrystals appeals to the pharmaceutical field. Indeed, until now, about 70 % of the potential drug candidates are discarded due to low bioavailability related with poor solubility in water. Since a modern and efficient design strategy for nanocrystal-based delivery systems requires the knowledge of the theoretical relation between nanocrystal size and solubility, the aim of this paper is to build up a physically-oriented thermodynamic model relating to nanocrystal dimensions with their melting temperature, enthalpy, solubility and dissolution rate. In particular, the developed model will be applied to vinpocetine, a poorly soluble drug used in the treatment of various types of cerebrovascular circulatory disorders.

Ključne riječi

nanocrystals; drug; solubility; dissolution; thermodynamic model

Hrčak ID:

128026

URI

https://hrcak.srce.hr/128026

Datum izdavanja:

10.10.2014.

Posjeta: 1.513 *