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Pregledni rad
Intramolecular Autoregulatory Sequences in Proteins
Bostjan Kobe
orcid.org/0000-0001-9413-9166
; Department of Biochemistry and Molecular Biology, and Institute for Molecular Bioscience, University of Queenslandy Brisbane 4072, Australia
| Puni tekst: engleski, pdf (177 KB) | str. 805-816 | citiraj | |
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APA 6th Edition Kobe, B. (2002). Intramolecular Autoregulatory Sequences in Proteins. Croatica Chemica Acta, 75 (3), 805-816. Preuzeto s https://hrcak.srce.hr/129323 MLA 8th Edition Kobe, Bostjan. "Intramolecular Autoregulatory Sequences in Proteins." Croatica Chemica Acta, vol. 75, br. 3, 2002, str. 805-816. https://hrcak.srce.hr/129323. Citirano 01.03.2021. Chicago 17th Edition Kobe, Bostjan. "Intramolecular Autoregulatory Sequences in Proteins." Croatica Chemica Acta 75, br. 3 (2002): 805-816. https://hrcak.srce.hr/129323 Harvard Kobe, B. (2002). 'Intramolecular Autoregulatory Sequences in Proteins', Croatica Chemica Acta, 75(3), str. 805-816. Preuzeto s: https://hrcak.srce.hr/129323 (Datum pristupa: 01.03.2021.) Vancouver Kobe B. Intramolecular Autoregulatory Sequences in Proteins. Croatica Chemica Acta [Internet]. 2002 [pristupljeno 01.03.2021.];75(3):805-816. Dostupno na: https://hrcak.srce.hr/129323 IEEE B. Kobe, "Intramolecular Autoregulatory Sequences in Proteins", Croatica Chemica Acta, vol.75, br. 3, str. 805-816, 2002. [Online]. Dostupno na: https://hrcak.srce.hr/129323. [Citirano: 01.03.2021.] |
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Sažetak
The worldwide structural genomics initiative promises, within the next decade, to provide us with the three-dimensional structures of most representative proteins. However, the initiative does not in the initial stages specifically address the structural basis of protein-protein interactions and protein regulation, both of which are crucial for understanding the cellular function of proteins. This report reviews the studies of the structural basis of protein-protein interactions and regulation in several biologically important cellular processes carried out in our laboratory. The focus will be on the recognition of nuclear localization sequences (NLSs) by the nuclear import factor importin-α, and its regulation. Regulatory interactions in retroviral envelope proteins and the enzyme phenylalanine hydroxylase (PAH) will be discussed also. Ali three biological systems share a regulatory mechanism termed active sitedirected or intrasteric regulation.
Ključne riječi
active site-directed/intrasteric regulation; importin-α/ karyopherin-α, membrane fusion; nuclear localization signal; phenylalanine hydroxylase; protein-protein interactions; protein structure; viral envelope proteins; X-ray crystallography
Hrčak ID: 129323
URI
https://hrcak.srce.hr/129323
Moj profil
Srce