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https://doi.org/10.5562/cca2360

Palladium Complexes with 3-Substituted Derivatives of 5-Methyl-5-(4-pyridyl)hydantoins. Synthesis, Study and in vitro Cytotoxicity

Adriana Bakalova ; Department of Chemistry, Faculty of Pharmacy, Medical University - Sofia, 2 Dunav Str., 1000 Sofia, Bulgaria
Rossen Buyukliev ; Department of Chemistry, Faculty of Pharmacy, Medical University - Sofia, 2 Dunav Str., 1000 Sofia, Bulgaria
Georgi Momekov ; Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University - Sofia, 2 Dunav Str., 1000 Sofia, Bulgaria

Puni tekst: engleski, pdf (1 MB) str. 195-199 preuzimanja: 638* citiraj
APA 6th Edition
Bakalova, A., Buyukliev, R. i Momekov, G. (2014). Palladium Complexes with 3-Substituted Derivatives of 5-Methyl-5-(4-pyridyl)hydantoins. Synthesis, Study and in vitro Cytotoxicity. Croatica Chemica Acta, 87 (3), 195-199. https://doi.org/10.5562/cca2360
MLA 8th Edition
Bakalova, Adriana, et al. "Palladium Complexes with 3-Substituted Derivatives of 5-Methyl-5-(4-pyridyl)hydantoins. Synthesis, Study and in vitro Cytotoxicity." Croatica Chemica Acta, vol. 87, br. 3, 2014, str. 195-199. https://doi.org/10.5562/cca2360. Citirano 27.02.2021.
Chicago 17th Edition
Bakalova, Adriana, Rossen Buyukliev i Georgi Momekov. "Palladium Complexes with 3-Substituted Derivatives of 5-Methyl-5-(4-pyridyl)hydantoins. Synthesis, Study and in vitro Cytotoxicity." Croatica Chemica Acta 87, br. 3 (2014): 195-199. https://doi.org/10.5562/cca2360
Harvard
Bakalova, A., Buyukliev, R., i Momekov, G. (2014). 'Palladium Complexes with 3-Substituted Derivatives of 5-Methyl-5-(4-pyridyl)hydantoins. Synthesis, Study and in vitro Cytotoxicity', Croatica Chemica Acta, 87(3), str. 195-199. https://doi.org/10.5562/cca2360
Vancouver
Bakalova A, Buyukliev R, Momekov G. Palladium Complexes with 3-Substituted Derivatives of 5-Methyl-5-(4-pyridyl)hydantoins. Synthesis, Study and in vitro Cytotoxicity. Croatica Chemica Acta [Internet]. 2014 [pristupljeno 27.02.2021.];87(3):195-199. https://doi.org/10.5562/cca2360
IEEE
A. Bakalova, R. Buyukliev i G. Momekov, "Palladium Complexes with 3-Substituted Derivatives of 5-Methyl-5-(4-pyridyl)hydantoins. Synthesis, Study and in vitro Cytotoxicity", Croatica Chemica Acta, vol.87, br. 3, str. 195-199, 2014. [Online]. https://doi.org/10.5562/cca2360

Sažetak
Six palladium(II) and palladium(IV) complexes with 3-ethyl-5-methyl-5-(4-pyridyl)hydantoin, 3-propyl-5-methyl-5-(4-pyridyl)hydantoin and 3-benzyl-5-methyl-5-(4-pyridyl)hydantoin were synthe-sized. The complexes were identified and characterized by elemental analysis, IR, 1H, 13C NMR spec-tra etc. On the data obtained the molecular formulae of the new palladium complexes were proposed. The
cytotoxicity of the complexes was evaluated in vitro using a panel of human tumour cell lines. The re-sults demonstrate that the Pd(II) complex with 3-benzyl-5-methyl-5-(4-pyridyl)hydantoin exerts cyto-toxicity as compared to the other studied Pd(II) complexes in all tested cell lines.

Ključne riječi
Pd(II) and Pd(IV) complexes; 3,5-disubstituted hydantoins; cytotoxicity

Hrčak ID: 130426

URI
https://hrcak.srce.hr/130426

Posjeta: 917 *