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The effects of intra-articular tramadol administration on histopathological indices in rat knee joints.

Rahmat A. Fatahian Dehkordi ; Department of Basic Sciences, Faculty of Veterinary Medicine, University of Shahrekord, Shahrekord, Iran
Amin Bigham-Sadegh ; Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Shahrekord, Shahrekord, Iran
Naser Vajdi ; Postgraduate of University of Shahrekord, Shahrekord, Iran

Puni tekst: engleski, pdf (229 KB) str. 667-676 preuzimanja: 284* citiraj
APA 6th Edition
Fatahian Dehkordi, R.A., Bigham-Sadegh, A. i Vajdi, N. (2014). The effects of intra-articular tramadol administration on histopathological indices in rat knee joints.. Veterinarski arhiv, 84 (6), 667-676. Preuzeto s https://hrcak.srce.hr/130430
MLA 8th Edition
Fatahian Dehkordi, Rahmat A., et al. "The effects of intra-articular tramadol administration on histopathological indices in rat knee joints.." Veterinarski arhiv, vol. 84, br. 6, 2014, str. 667-676. https://hrcak.srce.hr/130430. Citirano 24.07.2019.
Chicago 17th Edition
Fatahian Dehkordi, Rahmat A., Amin Bigham-Sadegh i Naser Vajdi. "The effects of intra-articular tramadol administration on histopathological indices in rat knee joints.." Veterinarski arhiv 84, br. 6 (2014): 667-676. https://hrcak.srce.hr/130430
Harvard
Fatahian Dehkordi, R.A., Bigham-Sadegh, A., i Vajdi, N. (2014). 'The effects of intra-articular tramadol administration on histopathological indices in rat knee joints.', Veterinarski arhiv, 84(6), str. 667-676. Preuzeto s: https://hrcak.srce.hr/130430 (Datum pristupa: 24.07.2019.)
Vancouver
Fatahian Dehkordi RA, Bigham-Sadegh A, Vajdi N. The effects of intra-articular tramadol administration on histopathological indices in rat knee joints.. Veterinarski arhiv [Internet]. 2014 [pristupljeno 24.07.2019.];84(6):667-676. Dostupno na: https://hrcak.srce.hr/130430
IEEE
R.A. Fatahian Dehkordi, A. Bigham-Sadegh i N. Vajdi, "The effects of intra-articular tramadol administration on histopathological indices in rat knee joints.", Veterinarski arhiv, vol.84, br. 6, str. 667-676, 2014. [Online]. Dostupno na: https://hrcak.srce.hr/130430. [Citirano: 24.07.2019.]

Sažetak
The aim of this study was to investigate the effect of intra-articular injections of saline and tramadol on the articular cartilage in rat knee joints. Twenty-five adult Wistar rats were used in this experiment. They were randomly assigned to two groups, control (n = 5) and experimental (n = 20) and the latter was subdivided into four groups (each group n = 5). Saline was administered intra-articularly into the knee joints in the controls (group 1) and tramadol with different doses was injected into the knee joints of the experimental groups. In groups 2, 3, 4 and 5 different concentrations, 0.1, 0.25, 1.0 and 2.5 mg/mL respectively, of available tramadol were administrated intra-articularly into the knee joints. The results showed that there were no pathological changes in the saline-treated control joints (P>0.05). Joints treated with tramadol displayed significantly more pathological changes than the saline joints (P<0.05). Group 5 (2.5 mg/mL) showed maximum pathological changes as compared to the other treatment groups and saline injection. Histological results in all parameters showed that there was no significant difference between joints that received tramadol in group 2, compared to saline-treated joints (P>0.05). Joints that received tramadol in group 3 (0.25 mg/mL) showed no significant difference as compared with control joints in all histological indices, except for cell count. Joints treated with tramadol in groups 4 and 5 revealed significant histological changes compared to control joints in all histological indices. We conclude that intra-articular tramadol in high dosages (especially 2.5 mg/mL) causes histopathological changes in rat knee joints.

Ključne riječi
histopathology; knee joint; rat; saline; tramadol

Hrčak ID: 130430

URI
https://hrcak.srce.hr/130430

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Posjeta: 454 *