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https://doi.org/10.5562/cca2399

Effect of Adamantyl Compounds on Dynamics of Spin Labelled Multilamellar Liposomes

Krunoslav Mirosavljević ; College of Slavonski Brod, Dr. Mile Budaka 1, HR-35000 Slavonski Brod, Croatia;Department of Physical Chemistry, Ruđer Bošković Institute, Bijenička cesta 54,10000 Zagreb, Croatia
Marija Matković ; Department of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb
Kata Mlinarić-Majerski ; Department of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb
Vesna Noethig-Laslo ; Department of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb

Puni tekst: engleski, pdf (2 MB) str. 249-253 preuzimanja: 497* citiraj
APA 6th Edition
Mirosavljević, K., Matković, M., Mlinarić-Majerski, K. i Noethig-Laslo, V. (2014). Effect of Adamantyl Compounds on Dynamics of Spin Labelled Multilamellar Liposomes. Croatica Chemica Acta, 87 (3), 249-253. https://doi.org/10.5562/cca2399
MLA 8th Edition
Mirosavljević, Krunoslav, et al. "Effect of Adamantyl Compounds on Dynamics of Spin Labelled Multilamellar Liposomes." Croatica Chemica Acta, vol. 87, br. 3, 2014, str. 249-253. https://doi.org/10.5562/cca2399. Citirano 15.11.2019.
Chicago 17th Edition
Mirosavljević, Krunoslav, Marija Matković, Kata Mlinarić-Majerski i Vesna Noethig-Laslo. "Effect of Adamantyl Compounds on Dynamics of Spin Labelled Multilamellar Liposomes." Croatica Chemica Acta 87, br. 3 (2014): 249-253. https://doi.org/10.5562/cca2399
Harvard
Mirosavljević, K., et al. (2014). 'Effect of Adamantyl Compounds on Dynamics of Spin Labelled Multilamellar Liposomes', Croatica Chemica Acta, 87(3), str. 249-253. https://doi.org/10.5562/cca2399
Vancouver
Mirosavljević K, Matković M, Mlinarić-Majerski K, Noethig-Laslo V. Effect of Adamantyl Compounds on Dynamics of Spin Labelled Multilamellar Liposomes. Croatica Chemica Acta [Internet]. 2014 [pristupljeno 15.11.2019.];87(3):249-253. https://doi.org/10.5562/cca2399
IEEE
K. Mirosavljević, M. Matković, K. Mlinarić-Majerski i V. Noethig-Laslo, "Effect of Adamantyl Compounds on Dynamics of Spin Labelled Multilamellar Liposomes", Croatica Chemica Acta, vol.87, br. 3, str. 249-253, 2014. [Online]. https://doi.org/10.5562/cca2399

Sažetak
Interactions of two adamantyl molecules: 3-(adamantan-1-yl)propan-1-aminium chloride
(compound A) and 1-hydroxyadamantan (compound B) with multilayer liposomes composed of
L-α-phosphatidylcholine, cholesterol and dicetylphosphate, spin labelled with n-doxylstearic acids (n = 5, 7, 10, 12, 16) were investigated. In the presence of aminium salt (A) or alcohol (B) the increased dy-namics of 5-doxylstearic acids and 16-doxylstearic acids in the multilamellar liposomes were determined in the temperature range from 250 K to 295 K. The increased dynamics of 5-doxylstearic acids suggest-ed that both adamantyl compounds influenced molecular motions in the interfacial region of the lipo-some. The increased motional properties of 16-doxylstearic acids, located in the core of the multilamel-lar liposomes, suggested that both adamantyl compounds induced the structural changes in the hydro-phobic core as well.

Ključne riječi
adamantyl compounds; drug transport; drug interactions; physicochemical properties; spin labelling; ESR; spectroscopy; liposomes; phospholipids

Hrčak ID: 130519

URI
https://hrcak.srce.hr/130519

Posjeta: 677 *