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Croatica Chemica Acta, Vol.72 No.2-3 Rujan 1999.

Pregledni rad

Structure and Cytotoxic Properties of Some Selected Gold(III) Complexes

Bruno Bruni ; Department of Chemistry, University of Florence, Florence, Italy
Annalisa Guerri ; Department of Chemistry, University of Florence, Florence, Italy
Giordana Marcon ; Department of Chemistry, University of Florence, Florence, Italy
Luigi Messori ; Department of Chemistry, University of Florence, Florence, Italy
Pierluigi Orioli ; Department of Chemistry, University of Florence, Florence, Italy

Puni tekst: engleski, pdf (91 KB) str. 221-229 preuzimanja: 211* citiraj
APA 6th Edition
Bruni, B., Guerri, A., Marcon, G., Messori, L. i Orioli, P. (1999). Structure and Cytotoxic Properties of Some Selected Gold(III) Complexes. Croatica Chemica Acta, 72 (2-3), 221-229. Preuzeto s https://hrcak.srce.hr/132158
MLA 8th Edition
Bruni, Bruno, et al. "Structure and Cytotoxic Properties of Some Selected Gold(III) Complexes." Croatica Chemica Acta, vol. 72, br. 2-3, 1999, str. 221-229. https://hrcak.srce.hr/132158. Citirano 19.08.2018.
Chicago 17th Edition
Bruni, Bruno, Annalisa Guerri, Giordana Marcon, Luigi Messori i Pierluigi Orioli. "Structure and Cytotoxic Properties of Some Selected Gold(III) Complexes." Croatica Chemica Acta 72, br. 2-3 (1999): 221-229. https://hrcak.srce.hr/132158
Harvard
Bruni, B., et al. (1999). 'Structure and Cytotoxic Properties of Some Selected Gold(III) Complexes', Croatica Chemica Acta, 72(2-3), str. 221-229. Preuzeto s: https://hrcak.srce.hr/132158 (Datum pristupa: 19.08.2018.)
Vancouver
Bruni B, Guerri A, Marcon G, Messori L, Orioli P. Structure and Cytotoxic Properties of Some Selected Gold(III) Complexes. Croatica Chemica Acta [Internet]. 01.09.1999. [pristupljeno 19.08.2018.];72(2-3):221-229. Dostupno na: https://hrcak.srce.hr/132158
IEEE
B. Bruni, A. Guerri, G. Marcon, L. Messori i P. Orioli, "Structure and Cytotoxic Properties of Some Selected Gold(III) Complexes", Croatica Chemica Acta, vol.72, br. 2-3, str. 221-229, Kolovoz 2018. [Online]. Dostupno na: https://hrcak.srce.hr/132158. [Citirano: 19.08.2018.]

Sažetak
We prepared four representative square planar gold(III) complexes - [AuCl3(Hpm)], [AuCl2(esal)], [AuCl(dien)]Cl2 and [Au(en)2]Cl3 -and characterized them both in the solid state and in solution. Thereafter, the cytotoxicity of these compounds was evaluated in vitro against the A2780 human ovarian tumor cell line that was used as the reference cell line. Remarkably, ali these gold(III) complexes showed significant cytotoxic effects, [AuCl2(esal)] showing a potency comparable to cisplatin. The present gold(III) complexes were also tested on the corresponding cisplatin-resistant line and revealed they were able to overcome resistance to cisplatin to a large extent. The implications of these findings for the development of new gold(III) complexes to be tested as antitumor agents are discussed.

Ključne riječi
gold complexes; X-ray structure; antitumoral compounds; cytotoxicity

Hrčak ID: 132158

URI
https://hrcak.srce.hr/132158

Posjeta: 300 *